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Application Site of Transdermal Scopolamine Influences Efficacy and Drug Concentration in Salivary Glands in Rats.
Biol Pharm Bull
December 2023
Department of Clinical Pharmacy and Healthcare Sciences, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University.
Article Synopsis
- Transdermal scopolamine applied to the area behind the ear is effective in reducing drooling in rats, with different application sites influencing its effectiveness.
- The study found that applying scopolamine ointment directly over the salivary glands resulted in a more significant reduction in saliva volume compared to applying it on the back.
- Higher concentrations of scopolamine were detected in the salivary glands when the ointment was applied over them, indicating that this method may be an efficient treatment option for drooling.
Successful treatment of enterocutaneous fistula after esophagectomy with scopolamine ointment and negative pressure wound therapy: a case report.
Surg Case Rep
July 2020
Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.
Background: Despite improved surgical techniques and perioperative management, anastomotic leakage (AL) after esophageal cancer surgery remains a potential complication. In most cases, spontaneous healing upon proper drainage is observed, but sometimes, AL results in intractable enterocutaneous fistulas. We here report a case of intractable enterocutaneous fistula caused by post-esophagectomy AL and successfully treated by scopolamine ointment and negative pressure wound therapy (NPWT).
View Article and Find Full Text PDFScreening of drugs and homeopathic products from Atropa belladonna seed extracts: Tropane alkaloids determination and untargeted analysis.
Drug Test Anal
October 2018
Department of Chemistry and Physics, Analytical Chemistry Area, University of Almería, Research Centre for Agricultural and Food Biotechnology (BITAL), Agrifood Campus of International Excellence ceiA3, Almería, Spain.
Homeopathic products are still a controversial issue in modern medicine, understood as complementary or alternative medicine (CAM). In this particular case, homeopathic products prepared from Atropa belladonna extracts may present specific problems due to the effects derived from its components. This article applies a simple, rapid, reliable method to the analysis of different homeopathic products obtained from Atropa belladonna; drugs containing high concentration of plant extracts; and Atropa belladonna seeds.
View Article and Find Full Text PDFEffectiveness of the repeated administration of scopolamine ointment on clozapine-induced hypersalivation in patients with treatment-resistant schizophrenia: A preliminary study.
Asia Pac Psychiatry
December 2017
Office of Clinical Pharmacy Practice and Health Care Management, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Introduction: This study investigated the efficacy of scopolamine (an anticholinergic agent) ointment against clozapine-induced hypersalivation.
Methods: The patients enrolled in this study consisted of 10 clozapine-treated schizophrenia patients and 10 healthy adult men. A prospective, randomized, double-blind, crossover, placebo-controlled clinical trial was designed.
Scopolamine Ointment for Clozapine-Associated Sialorrhea: A Case Report.
J Clin Psychopharmacol
February 2017
Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Japan Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan Department of Pharmacy, University of Fukui Hospital, Fukui, Japan Health Administration Center, University of Fukui, Fukui, Japan Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
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