Nucleophilic F-fluorination of bromodifluoromethyl derivatives was performed using [F]BuNF in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). This novel procedure provided a diverse set of [F]trifluoroacetamides in good to excellent radiochemical conversions. A mechanism where DBU acts as organomediator in this transformation is proposed.
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| http://dx.doi.org/10.1039/c6cc08535k | DOI Listing |
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