AI Article Synopsis
- Mitochondrial dysfunction is linked to cancer and obesity, with a focus on prostate cancer's severity in obese men, highlighting the role of mitochondrial transcription factor A (TFAM).
- The study aimed to explore the relationship between three specific TFAM genetic variations and aggressive prostate cancer in overweight or obese Mexican Mestizo men, using a sample of 257 patients.
- While no significant link was found with individual polymorphisms, one specific haplotype showed a notable association with cancer aggressiveness, marking a first step in understanding this genetic influence on prostate cancer severity.
Article Abstract
Background: Mitochondrial dysfunction has been associated with the development of cancer and obesity, being prostate cancer more aggressive in obese men. It has been suggested that the mitochondrial transcription factor A (TFAM) plays a central role in these events.
Objective: The aim of this study was to analyze the possible association of 3 TFAM polymorphisms, as well as their haplotypes, with the development of aggressive prostate cancer in overweight or obese Mexican Mestizo men.
Subjects And Methods: A total of 257 unrelated men with histologically confirmed prostate cancer, of Mexican Mestizo ethnic origin, were included. Body mass index was determined and the degree of prostate cancer aggressiveness was demarcated by the D'Amico classification. DNA was obtained from blood leukocytes. The rs1937, rs1049432, and rs11006132, as well as their haplotypes, were studied by real-time polymerase chain reaction allelic discrimination. Deviations from Hardy-Weinberg equilibrium were tested. Pairwise linkage disequilibrium between single nucleotide polymorphisms was calculated; haplotype analysis was performed.
Results: A higher risk (D'Amico classification) was documented in 56 patients (21.8%). We did not find a significant association among those polymorphisms analyzed; however, one haplotype was significantly associated with cancer aggressiveness.
Conclusions: To our knowledge, this constitutes the first study regarding the relationship of 3 TFAM polymorphisms, as well as their haplotypes, and the aggressiveness of prostate cancer in overweight or obese men; the most frequent haplotype was associated with cancer aggressiveness.
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| http://dx.doi.org/10.1016/j.urolonc.2016.10.011 | DOI Listing |
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