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Unlabelled: Although tryptophan (Trp) is the largest and most structurally complex amino acid, it is the least abundant in the proteome. Its distinct indole ring and high carbon content enable it to generate various biologically active metabolites such as serotonin, kynurenine (Kyn), and indole-3-pyruvate (I3P). Dysregulation of Trp metabolism has been implicated in diseases ranging from depression to cancer.
View Article and Find Full Text PDFA bifunctional endolytic alginate lyase with two different lyase catalytic domains from sp. H204.
Front Microbiol
December 2024
Key Laboratory of Agro-Products Processing Technology of Shandong Province, Key Laboratory of Novel Food Resources Processing Ministry of Agriculture, Institute of Food & Nutrition Science and Technology, Shandong Academy of Agricultural Sciences, Jinan, China.
Alginate lyases can fully degrade alginate into various size-defined unsaturated oligosaccharide products by -elimination. Here, we identified the bifunctional endolytic alginate lyase Aly35 from the marine bacterium sp. Strain H204.
View Article and Find Full Text PDFEffects of C-ring structures on the formations of flavonoid semiquinones and their binding behavior with β-lactoglobulin as revealed by experimental and modeling approaches.
Int J Biol Macromol
December 2024
Key Laboratory of Forest Food Resources Utilization of Heilongjiang Province, Harbin 150040, China; College of Life Sciences, Northeast Forestry University, Harbin 150040, China. Electronic address:
The present study investigated the covalent binding behavior of the flavonoids, catechin, eriodictyol, luteolin and quercetin with β-lactoglobulin (βlg). Since the four flavonoids possess the identical A- and B-ring structures, effects of the C-rings on the properties of flavonoids and the corresponding semiquinones are revealed. Experimental methods including DLS and CD spectra indicated that with quercetin at room temperature did not induce aggregation of βlg, whilst binding with the other three flavonoids resulted in aggregation of βlg.
View Article and Find Full Text PDFExploring tryptophan metabolism in cardiometabolic diseases.
Trends Endocrinol Metab
December 2024
Université Paris Cité, Inserm, PARCC, F-75015 Paris, France. Electronic address:
Tryptophan (Trp) metabolism is linked to health and disease, with indoleamine 2,3-dioxygenase 1 (IDO) being a key enzyme in its breakdown outside the liver. This process produces metabolites that influence metabolic and inflammatory responses. A distinctive feature of the gut is its involvement in three major Trp catabolic pathways: the IDO-driven kynurenine pathway, bacteria-produced indoles, and serotonin.
View Article and Find Full Text PDFDistribution, frequency and molecular basis of penoxsulam, metamifop and florpyrauxifen-benzyl resistance in Echinocloa spp. from rice fields across Jiangsu Province, China.
Pestic Biochem Physiol
January 2025
College of Plant Protection, Yangzhou University, Yangzhou, China. Electronic address:
Barnyard grasses (Echinochloa spp.) are the most troublesome weeds in rice ecosystems of Jiangsu Province, China, and long-term use of herbicides inevitably cause the development of resistance. In this study, 122 field-sampled populations were tested for resistance to penoxsulam (PEN), metamifop (MET), florpyrauxifen-benzyl, (FPB), propanil, and tripyrasulfone.
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