Purpose: Children's early onset of cannabis use was examined as a function of their parent's early onset of cannabis and subsequent incidence of a lifetime cannabis abuse or dependence disorder.
Methods: Prospective, longitudinal data from the Rochester Youth Development Study and the Rochester Intergenerational Study for 442 parent-child dyads (274 father-child, 168 mother-child) were used. The children were evenly split by sex. Logistic regression models and a path analysis were estimated to assess the effect of parent's cannabis use on child's onset of cannabis by age 15.
Results: Fathers who began using cannabis by age 15 were more likely to meet the criteria for a lifetime cannabis disorder (odds ratio = 5.66, 95% confidence interval = 1.89-16.90). The offspring of fathers who met the criteria for a disorder had higher odds of early initiation of cannabis use (odds ratio = 9.70, 95% confidence interval = 3.00-31.34). Early-onset cannabis use by father was indirectly associated with their child's onset of cannabis use via father's lifetime cannabis disorder. No significant effects for mothers were observed, although analyses were limited due to the low rate of mothers who met the criteria for a lifetime cannabis disorder.
Conclusions: This study provides evidence of intergenerational continuity in cannabis use among fathers and their children and confirms the need to consider timing of use and intervening mechanisms in the study of continuity in cannabis use across generations.
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http://dx.doi.org/10.1016/j.jadohealth.2016.09.005 | DOI Listing |
Zool Res
January 2025
Institute of Brain Science and Disease, School of Basic Medicine, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, Shandong 266071, China. E-mail:
Substantial evidence points to the early onset of peripheral inflammation in the development of Parkinson's disease (PD), supporting the "body-first" hypothesis. However, there remains a notable absence of PD-specific animal models induced by inflammatory cytokines. This study introduces a novel mouse model of PD driven by the proinflammatory cytokine CXCL1, identified in our previous research.
View Article and Find Full Text PDFAnn Surg
January 2025
Hubei Key Laboratory of Ischemic Cardiovascular Disease, Yichang, China.
Objective: The aim of this study is to explore the risk profiles associated with Abdominal aortic aneurysm (AAA) incidence in both the general population and diverse subpopulations.
Summary Background Data: AAA is a life-threatening arterial disease, and there is limited understanding of its etiological spectrum across the age, sex, and genetic risk subgroups, making early prevention efforts more complicated.
Methods: This study encompassed a sample size of 364399 participants from the UK.
Front Immunol
January 2025
Department of Rheumatology & Allergology, Japanese Red Cross Medical Center, Tokyo, Japan.
Patients with A20 haploinsufficiency (HA20) presenting with central nervous system (CNS) symptoms are rare, and available reports are limited. Here, we describe a patient with HA20, previously followed up as Behçet disease, who presented with CNS symptoms in adulthood. A 38-year-old Japanese male who had been followed up for incomplete Behçet disease at another hospital since 28 years of age presented to our hospital with acute-onset diplopia and persistent hiccups that were severe enough to cause vomiting.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China.
Objective: This study aimed to evaluate the risk of tumor formation with infliximab or azathioprine monotherapy versus their combination, using the FDA Adverse Event Reporting System (FAERS) database.
Methods: Data were extracted from the FAERS database for patients treated with infliximab, azathioprine, and combination therapy from Q1 2004 to Q2 2024. Signal mining employed methods such as Reported Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Multiple Gamma-Poisson Scaling Assessment (MGPSA) and Bayesian Confidence Interval Progressive Neural Network (BCPNN).
Brain Commun
January 2025
Queensland Aphasia Research Centre, University of Queensland, Brisbane 4029, Australia.
The integrity of the frontal segment of the corpus callosum, forceps minor, is particularly susceptible to age-related degradation and has been associated with cognitive outcomes in both healthy and pathological ageing. The predictive relevance of forceps minor integrity in relation to cognitive outcomes following a stroke remains unexplored. Our goal was to evaluate whether the heterogeneity of forceps minor integrity, assessed early after stroke onset (2-6 weeks), contributes to explaining variance in longitudinal outcomes in post-stroke aphasia.
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