Introduction: In the medical field, nanoparticles (NP) Fe3O4 are currently considered to be a relatively inert carrier for therapeutic and diagnostic pharmaceuticals, and they are also presumed for intravenous (i.v.) administration. Because they have nano dimensions, they probably can penetrate through various membranes and pass from the bloodstream to other organs in the body (Borm P, Muller-Schulte D. Nanoparticles in medicine, 2007, Chapter 21, pp. 387-413, Particle Toxicology, ed. Donaldson K, Borm P, Taylor & Francis Group, USA, 434 p., ISBN 0-8493-5092-1). Therefore, in our experiment, we have examined the impact of a NP Fe3O4 instilled i.v. (to a tail vein of an animal) on the select parameters of bronchoalveolar lavage (BAL). The aim of our study was to determine whether the NP investigated by us, pass through the vascular system to the respiratory tract, and if so, how they affect the selected inflammatory and cytotoxic parameters of BAL.
Materials And Methods: Wistar rats were intravenously given a suspension of Fe3O4 and after time intervals of 1, 7, 14 and 28 days, the animals were sacrificed, BAL was performed and selected inflammatory and cytotoxic BAL parameters were examined.
Conclusion: Based on the results obtained by us, Fe3O4 NP exposure, compared to the control, induced inflammatory response, the cytotoxic damage and respiratory toxicity. The results further show that Fe3O4 NP, 28 days after i.v. instillation, were eliminated from the respiratory tract by defense mechanisms.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1515/reveh-2016-0022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anti-IL-5 treatment, but not neutrophil interference, attenuates inflammation in a mixed granulocytic asthma mouse model, elicited by air pollution.
Respir Res
January 2025
Department of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Medical Research Building (MRB) II, Ghent University Hospital, 2 Floor, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Introduction: Diesel exhaust particles (DEP) have been proven to aggravate asthma pathogenesis. We previously demonstrated that concurrent exposure to house dust mite (HDM) and DEP in mice increases both eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) and also results in higher levels of neutrophil-recruiting chemokines and neutrophil extracellular trap (NET) formation compared to sole HDM, sole DEP or saline exposure. We aimed to evaluate whether treatment with anti-IL-5 can alleviate the asthmatic features in this mixed granulocytic asthma model.
View Article and Find Full Text PDFThe degree of cross-linking of polyacrylic acid affects the fibrogenicity in rat lungs.
Sci Rep
January 2025
Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan.
Polyacrylic acid (PAA) with different concentrations of cross-linker was instilled into the trachea of rats to examine the effect of PAA crosslink density on lung disorders. Methods: F344 rats were intratracheally exposed to low and high doses of PAA with cross-linker concentrations of 0.1, 1.
View Article and Find Full Text PDFPrevious treatment with anthracycline does not affect the course of sepsis in cancer patients: Retrospective cohort study.
J Intensive Med
January 2025
Medical Intensive Care Unit, APHP Saint-Louis University Hospital, Paris, France.
Background: Cancer patients who are exposed to sepsis and had previous chemotherapy may have increased severity. Among chemotherapeutic agents, anthracyclines have been associated with cardiac toxicity. Like other chemotherapeutic agents, they may cause endothelial toxicity.
View Article and Find Full Text PDFNebulized aminoglycosides for ventilator-associated pneumonia: Methodological considerations and lessons from experimental studies.
J Intensive Med
January 2025
Department of Pneumology, Institut Clinic del Tórax, Hospital Clinic of Barcelona - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona - SGR 911- Ciber de Enfermedades Respiratorias (Ciberes), Barcelona, Spain.
Aminoglycosides are concentration-dependent antibiotics exerting a bactericidal effect when concentrations at the site of infection are equal to or greater than 5 times the minimum inhibitory concentrations (MIC). When administered intravenously, they exhibit poor lung penetration and high systemic renal and ototoxicity, imposing to restrict their administration to 5 days. Experimental studies conducted in anesthetized and mechanically ventilated sheep and pigs provide evidence that high doses of nebulized aminoglycosides induce a rapid and potent bacterial killing in the infected lung parenchyma.
View Article and Find Full Text PDFBackground: Occurrence of life-threatening scorpion sting in adults is a rare entity compared with children. Different cases of organ failure following scorpion sting have been reported but complications, such as acute toxic myocarditis, cardiogenic shock, pulmonary edema, acute kidney injury and toxic hepatitis occurring simultaneously in adult patients is exceedingly rare with no prior documented similar report. This case report explores the unique presentation of these complications occurring simultaneously and their management in resource limited setting.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!