AI Article Synopsis
- The review focused on the role of microRNAs (miRNAs) in regulating gene expression related to myopia development.
- Recent research highlighted specific miRNAs associated with myopia, such as miR-328 and miR-184, and noted their expression in human fetal sclera.
- Understanding miRNA profiles could enhance diagnostic and treatment strategies for myopia in the future.
Article Abstract
Purpose: In recent years, research on microRNAs (miRNAs) has become popular because of the critical role these macromolecules play in post-transcriptional gene regulation. Recent efforts have been made to identify miRNAs and their possible roles in myopia. The aim of this review was to summarize the expression and function of miRNAs during the development of myopia.
Methods: In this article, we reviewed the current research on the mechanisms that regulate miRNA expression, the potential for miRNAs as a diagnostic biomarker for myopia, and the mechanisms by which miRNAs promote the development of myopia. We also discussed the miRNA expression profiles in human fetal sclera.
Results: We summarized the miRNA expression profiles in myopia, including miR-328, miR-184, miR-29a, and miR-let-7i, and also the miRNA expression profiles in fetal sclera, including miR-214, miR-let-7, miR-103, miR-107, miR-29b, miR-328, and miR-98.
Conclusions: Such knowledge could lead to more precise diagnosis, prognosis, and response predictions for future treatments for myopia, and the pace of discovery is expected to accelerate dramatically in the near future.
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| http://dx.doi.org/10.1007/s00417-016-3532-6 | DOI Listing |
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