AI Article Synopsis
- A 2-year-old girl, who was previously healthy and vaccinated for chickenpox, developed herpes zoster on the left side of her face due to the vaccine-strain varicella-zoster virus (VZV) and recovered fully after intravenous acyclovir treatment.
- Earlier findings suggested that zoster rashes from vaccine-strain VZV typically appear at the vaccination site, but this girl's rash occurred in the trigeminal nerve area, not related to the vaccination site.
- The case highlights the need to differentiate between vaccine-strain and wild-type VZV in herpes zoster cases, even in healthy children, and suggests that tracking vaccine-strain HZ incidence can help understand the safety of the varicella vaccine better
Article Abstract
A previously healthy 2-year-old girl, vaccinated for varicella at 17 months, was admitted because of left-sided facial herpes zoster caused by vaccine-strain varicella-zoster virus (VZV). She recovered fully with no complication after intravenous treatment using acyclovir. Earlier reports have described that herpes zoster (HZ) rashes caused by vaccine-strain VZV tend to occur on the dermis corresponding to the skin area where the varicella vaccine was received. However, rashes appeared on this girl only in the trigeminal nerve area, which is unrelated to the vaccinated site. Results underscore the importance of distinguishing vaccine-strain VZV from wild-type VZV whenever encountering HZ cases after vaccination, even in immunocompetent children, irrespective of the skin lesion site. Monitoring vaccine-strain HZ incidence rates is expected to elucidate many aspects of varicella vaccine safety.
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| http://dx.doi.org/10.1016/j.jcv.2016.10.022 | DOI Listing |
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