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| http://dx.doi.org/10.1038/bcj.2016.108 | DOI Listing |
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RANKL regulates differentially breast cancer stem cell properties through its RANK and LGR4 receptors.
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Innovation and Precision Medicine Laboratory, Instituto Nacional de Medicina Genómica, Periférico Sur No.4809, Col Arenal Tepepan, Tlalpan, Mexico City C.P. 14610, Mexico. Electronic address:
Background: Breast cancer stem cells (BCSC) are a subpopulation responsible for cancer resistance and relapse. The receptor activator of nuclear factor kappa-Β ligand (RANKL) is a cytokine capable of activating RANK and LGR4 receptors. RANKL/RANK signaling maintains the self-renewal of BCSCs, however, the effect of RANKL via LGR4 remains unclear.
View Article and Find Full Text PDFThe role of FOXM1 in acetylcysteine improving diabetic periodontitis.
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State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14 3rd Section, South Renmin Road, Chengdu, Sichuan, 610041, China.
Diabetic periodontitis (DP) stems from hyperglycemia-driven oxidative stress amplification and chronic inflammation, leading to periodontal tissue breakdown. Misregulated forkhead box protein M1 (FOXM1) play key roles in this process, exacerbating both inflammation and oxidative stress. In light of N-Acetylcysteine (NAC)'s potent anti-oxidative capacity and anti-inflammatory potential, understanding how it modulates these central pathways to alleviate DP holds high scientific and clinical importance.
View Article and Find Full Text PDFMolecular Mechanisms of Curdlan-Induced Suppression of NFATc1 Expression in Osteoclasts.
J Cell Biochem
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Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental University, Kitakyushu, Fukuoka, Japan.
Article Synopsis
- - Curdlan, a β-glucan, inhibits the formation of osteoclasts—cells that break down bone—by binding to dectin-1, leading to reduced expression of NFATc1, a key factor for osteoclast differentiation.
- - The study investigates how curdlan disrupts RANKL-induced NFATc1 expression and finds that it also affects the NF-κB signaling pathway, which is crucial for NFATc1 activation.
- - Additionally, the research indicates a dectin-1-independent mechanism involving complement receptor 3 (CR3), suggesting that curdlan's effects on osteoclast differentiation are multifaceted and involve multiple pathways.
ZIP4: a promising early diagnostic and therapeutic targets for pancreatic cancer.
Am J Cancer Res
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Department of Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai, PR China.
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- Pancreatic cancer is a highly aggressive cancer with poor early detection and treatment options, highlighting a need for better understanding of its molecular mechanisms and biomarkers.
- ZIP4, a zinc transporter protein that is overexpressed in pancreatic cancer, plays a crucial role in tumor growth and resistance by regulating zinc levels and influencing various transcriptional factors.
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A RANKL-UCHL1-sCD13 negative feedback loop limits osteoclastogenesis in subchondral bone to prevent osteoarthritis progression.
Nat Commun
October 2024
Department of Orthopaedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
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