This paper reports on contactless microparticle manipulation including single-particle controlled trapping, transportation, and patterning via single beam acoustic radiation forces. As the core component of single beam acoustic tweezers, a needle type ultrasonic transducer was designed and fabricated with center frequency higher than 300 MHz and -6 dB fractional bandwidth as large as 64%. The transducer was built for an -number close to 1.0, and the desired focal depth was achieved by press-focusing technology. Its lateral resolution was measured to be better than 6.7 m by scanning a 4 m tungsten wire target. Tightly focused acoustic beam produced by the transducer was shown to be capable of manipulating individual microspheres as small as 3 m. "USC" patterning with 15 m microspheres was demonstrated without affecting nearby microspheres. These promising results may expand the applications in biomedical and biophysical research of single beam acoustic tweezers.
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http://dx.doi.org/10.1063/1.4966285 | DOI Listing |
Clin Transl Radiat Oncol
January 2025
Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
Int J Radiat Oncol Biol Phys
January 2025
Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, FL, USA.
Objectives: Radiotherapy manages pancreatic cancer in various settings; however, the proximity of gastrointestinal (GI) luminal organs-at-risk (OAR) poses challenges to conventional radiotherapy. Proton beam therapy (PBT) may reduce toxicities compared to photon therapy. This consensus statement summarizes PBT's safe and optimal delivery for pancreatic tumors.
View Article and Find Full Text PDFPhys Med Biol
January 2025
The Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, Wuhan, Hubei, 430074, CHINA.
Objective: In-beam positron emission tomography (PET) has important development prospects in real-time monitoring of proton therapy. However, in the beam-on operation, the high bursts of radiation events pose challenges to the performance of the PET system.
Approach: In this study, we developed a dual-head in-beam PET system for proton therapy monitoring and evaluated its performance.
Ultrason Imaging
January 2025
Biomedical Ultrasound Imaging Laboratory, Department of Applied Mechanics and Biomedical Engineering, Indian Institute of Technology, Madras, Chennai, India.
Imaging depth remains a restriction for Synthetic Aperture (SA) approaches, even though SA techniques have been shown to overcome some of the drawbacks of Conventional Focused Beamforming (CFB) technique. This limitation is attributed to lesser energy per transmit in SA techniques compared to that of CFB technique. Therefore, in this paper, a systematic investigation is done to evaluate the improvement in imaging depth and image quality of B-mode ultrasound images in the case of SA technique using PZT transducer by boosting the input voltage to the transducer, while measuring the acoustic exposure parameters recommended in international standards.
View Article and Find Full Text PDFRep Pract Oncol Radiother
December 2024
Department of Radiation Oncology, Kagawa University Hospital, Kagawa, Japan.
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