Background/aims: Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats.
Methods: A total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery/medication (NSM), surgery/no medication (SNM), and surgery/medication (SM). Gastrointestinal transit (GIT), which is assessed by migration of charcoal, and cumulative stool weight were measured at 24 hours after surgery.
Results: GIT was significantly more delayed in the SNM group than in the other groups (SNM vs NSNM, < 0.001; SNM vs NSM, < 0.001; SNM vs SM, = 0.005). Cumulative stool weight in that group was also lower than in the no surgery groups (SNM vs NSNM, = 0.007; SNM vs NSM, = 0.033), and there was no significant difference between the SM group and the no surgery groups (SM vs NSM, = 0.703; SM vs NSNM, = 0.347).
Conclusion: DA-9701 can ameliorate POI by reducing delayed GIT and improving defecation in a rat model of POI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216641 | PMC |
| http://dx.doi.org/10.5056/jnm16003 | DOI Listing |
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