Background And Purpose: Hospitalist directed care is associated with improved outcomes in several medical conditions. The hospitalist effect has not been studied in acute ischemic stroke (AIS) patients. We compare length of stay (LOS), outcome, and adherence to "Get with the Guidelines" (GWTG) stroke quality measures among AIS patients admitted under a hospitalist with three other specialties (internist, family practice, or specialist).
Methods: We collected demographics, risk factors and discharge outcomes (modified Rankin Scale (mRS)) for consecutive AIS patients over 4-year period (2010-2014). We categorized all stroke admissions according to admitting physicians. We compared rates of adherence with all of the GWTG Stroke inpatient quality measures between the four groups.
Results: A total of 1584 patients [mean age ( ± SD) 68.6 ± 13.7 years; 55.6% men] were admitted with AIS. There was no statistically significant difference in LOS between the four groups (=0.4). There was significant difference in the GWTG inpatient quality measures with the hospitalist group having lowest rates of any nonadherence observed in 5% of admissions (=0.03), and the internists had the highest rate of nonadherence observed in 16% of admissions (=0.01). The most common deficiency was not prescribing statin at discharge (56% of total fallouts). There was no difference in rates of poor outcomes on discharge (mRS 3-6) (=0.2).
Conclusions: There was a significantly higher rate of adherence to GWTG inpatient stroke measures when AIS patients were admitted under the care of a hospitalist. Prospective studies are required to evaluate if higher rates of adherence lead to better long term outcomes.
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Eur J Med Res
January 2025
Division of Radiology, Saraburi Hospital, Saraburi, Thailand.
Introduction: Stroke-associated pneumonia (SAP) is a major cause of mortality during the acute phase of stroke. The ADS score is widely used to predict SAP risk but does not include 24-h non-contrast computed tomography-Alberta Stroke Program Early CT Score (NCCT-ASPECTS) or red cell distribution width (RDW). We aim to evaluate the added prognostic value of incorporating 24-h NCCT-ASPECTS and RDW into the ADS score and to develop a novel prediction model for SAP following thrombolysis.
View Article and Find Full Text PDFJ Neuroimaging
January 2025
Department of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
Background And Purpose: Prolonged venous transit (PVT), derived from computed tomography perfusion (CTP) time-to-maximum (T) maps, reflects compromised venous outflow (VO) in acute ischemic stroke due to large vessel occlusion (AIS-LVO). Poor VO is associated with worse clinical outcomes, but pre-treatment markers predictive of PVT are not well described.
Methods: We conducted a retrospective analysis of 189 patients with anterior circulation AIS-LVO who underwent baseline CT evaluation, including non-contrast CT, CT angiography, and CTP.
Medicine (Baltimore)
November 2024
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
This research aimed to assess the prognostic relevance of the hypoperfusion intensity ratio (HIR) concerning 90-day outcomes in patients with acute ischemic stroke (AIS) managed within the early intervention window. A retrospective review was conducted on AIS patients who received pretreatment computed tomography perfusion imaging and endovascular thrombectomy due to large vessel occlusions in the anterior circulation between January 2020 and September 2022. Clinical data, including the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) from non-contrast CT, along with perfusion metrics such as ischemic core, hypoperfusion extent, core-penumbra mismatch, and HIR, were analyzed.
View Article and Find Full Text PDFJ Clin Neurosci
January 2025
Comprehensive Centre for Stroke Care, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala 695011, India. Electronic address:
Background: The QT interval in ECG is susceptible to autonomic fluctuations, a known occurrence in acute ischemic stroke (AIS). Previous research has highlighted QT interval changes between ischemic and haemorrhagic strokes. However, there is scarce literature on the differential effect of AIS subtypes on QT interval.
View Article and Find Full Text PDFBMJ Open
December 2024
Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xian, China
Introduction: Despite the implementation of mechanical thrombectomy, acute ischaemic stroke with large vessel occlusion (AIS-LVO) remains a significant health concern, characterised by substantial morbidity and mortality. Our trial aims to evaluate the efficacy and safety of minocycline in reducing infarct volume and improving functional outcomes in patients undergoing mechanical thrombectomy for anterior circulation AIS-LVO.
Methods And Analysis: The MIST-A trial is a prospective, randomised, open-label, blinded-endpoint trial to be conducted across 12 medical centres.
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