AI Article Synopsis
- Noroviruses (NoVs) are the primary cause of gastroenteritis outbreaks globally, with a new variant known as GII.4 Sydney 2012 driving increased epidemic activity since late 2012.
- In Shenzhen, China, three significant NoV outbreaks occurred from late 2012 to early 2013, affecting two social welfare homes and a factory, with detection rates ranging from 26.2% to 59.3%.
- All NoV sequences from these outbreaks were identified as the GII.4 Sydney 2012 variant, including recombinant strains, indicating its role in the recent epidemics in the area.
Article Abstract
Noroviruses (NoVs) are the leading cause of gastroenteritis outbreaks in humans worldwide. Since late 2012, a new GII.4 variant Sydney 2012 has caused a significant increase in NoV epidemics in several countries. From November of 2012 to January of 2013, three gastroenteritis outbreaks occurred in two social welfare homes (Outbreaks A and B) and a factory (Outbreak C) in Shenzhen city of China. Feces and swabs were collected for laboratory tests for causative agents. While no bacterial pathogen was identified, all three outbreaks were caused by NoVs with detection rates of 26.2% (16/61) at Outbreak A, 35.2% (38/108) at Outbreak B), and 59.3% (16/27) at Outbreaks C. For Outbreak B, 25 of the 29 symptomatic individuals (86.2%) and 13 of the 79 asymptomatic individuals (16.5%) were found NoV-positive. For Outbreak C, an asymptomatic food handler was NoV-positive. All thirteen NoV sequences from the three outbreaks were classified into genogroup II and genotype 4 (GII.4), which we identified to be the GII.4 Sydney 2012 variant. The genome of two isolates from Outbreaks A and B were recombinant with the opening reading frame (ORF) 1 of GII.4 Osaka 2007 and ORF2 and 3 of the GII.4 New Orleans. Our study indicated that the GII.4 Sydney 2012 variant emerged and caused the outbreaks in China.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102426 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165880 | PLOS |
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