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Experience of dolutegravir in HIV-infected treatment-naive patients from a tertiary care University Hospital in Ireland. | LitMetric

Experience of dolutegravir in HIV-infected treatment-naive patients from a tertiary care University Hospital in Ireland.

SAGE Open Med

Infectious Diseases Department, Mater Misericordiae University Hospital, Dublin, Ireland; University College Dublin, Dublin, Ireland; Rotunda Hospital, Dublin, Ireland.

Published: October 2016

AI Article Synopsis

Article Abstract

Objective: Dolutegravir, an HIV integrase inhibitor, is a relatively new treatment option. To assess the tolerability, side effects, and time to viral decline to non-detectable in patients newly started on dolutegravir.

Methods: Retrospective health care record of 61 consecutive HIV treatment-naive patients started on dolutegravir was reviewed and analysed on SPSS.

Results: The mean initial viral load was 160826.05 copies/mL (range, 79-1,126,617 copies/mL). HIV viral load became non-detectable in 63.9% of patients on dolutegravir within 3 months. In all, 60.7% of patients reported no side effects on dolutegravir; 98.4% of the patients claimed full compliance to their antiretrovirals.

Conclusion: Dolutegravir was found to be efficacious and well tolerated in HIV-infected treatment-naive patients.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084612PMC
http://dx.doi.org/10.1177/2050312116675813DOI Listing

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