AI Article Synopsis
- * Marine sponges and tunicates are key sources of novel compounds that are crucial for drug discovery, with many of these compounds containing nitrogen and falling under non-ribosomal peptides (NRPs) or mixed polyketide-NRP categories.
- * Several of these pharmacologically active NRPs are in clinical trials aimed at developing new treatments for diseases such as cancer, neurodegenerative disorders, inflammation, and infections.
Article Abstract
Marine biodiversity is recognized by a wide and unique array of fascinating structures. The complex associations of marine microorganisms, especially with sponges, bryozoans, and tunicates, make it extremely difficult to define the biosynthetic source of marine natural products or to deduce their ecological significance. Marine sponges and tunicates are important source of novel compounds for drug discovery and development. Majority of these compounds are nitrogen containing and belong to non-ribosomal peptide (NRPs) or mixed polyketide-NRP natural products. Several of these peptides are currently under trial for developing new drugs against various disease areas, including inflammatory, cancer, neurodegenerative disorders, and infectious disease. This review features pharmacologically active NRPs from marine sponge and tunicates based on their biological activities.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078478 | PMC |
| http://dx.doi.org/10.3389/fphar.2016.00333 | DOI Listing |
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