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Reprogramming macrophage orientation by microRNA 146b targeting transcription factor IRF5. | LitMetric

Reprogramming macrophage orientation by microRNA 146b targeting transcription factor IRF5.

EBioMedicine

Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai,New York, NY 10029, United States; Institute of Immunology and Molecular Medicine, Jining Medical College, Jining, Shangdong 272067, China. Electronic address:

Published: December 2016

AI Article Synopsis

Article Abstract

The regulation of macrophage orientation pathological conditions is important but still incompletely understood. Here, we show that IL-10 and Rag1 double knockout mice spontaneously develop colitis with dominant M1 macrophage phenotype, suggesting that IL-10 regulates macrophage orientation in inflammation. We demonstrate that IL-10 stimulation induced miR-146b expression, and that the expression of miR-146b was impaired in IL-10 deficient macrophages. Our data show that miR-146b targets IRF5, resulting in the regulation of macrophage activation. Furthermore, miR-146b deficient mice developed intestinal inflammation with enhanced M1 macrophage polarization. Finally, miR-146b mimic treatment significantly suppresses M1 macrophage activation and ameliorates colitis development in vivo. Collectively, the results suggest that IL-10 dependent miR-146b plays an important role in the modulation of M1 macrophage orientation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161420PMC
http://dx.doi.org/10.1016/j.ebiom.2016.10.041DOI Listing

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