Bacterial chemical communication, through a process called quorum sensing (QS), plays a central role in infection in numerous bacterial pathogens. Quorum sensing in Pseudomonas aeruginosa employs a series of small molecule receptors including the master QS regulator, LasR. In this study we investigate a non-natural triaryl series of LasR ligands using a combination of structure activity relationship studies and computational modeling. These studies have enabled the identification of key structural requirements for ligand binding and have revealed a new strategy for inducing the therapeutically relevant antagonism of LasR.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2016.10.021DOI Listing

Publication Analysis

Top Keywords

quorum sensing
12
non-natural triaryl
8
pseudomonas aeruginosa
8
development novel
4
novel series
4
series non-natural
4
triaryl agonists
4
agonists antagonists
4
antagonists pseudomonas
4
lasr
4

Similar Publications

Microbial pathogens generate extracellular vesicles (EVs) for intercellular communication and quorum sensing. Microbial EVs also induce inflammatory pathways within host innate immune cells. We previously demonstrated that EVs secreted by trigger type I interferon signaling in host cells specifically via the cGAS-STING innate immune signaling pathway.

View Article and Find Full Text PDF

Photodynamic bactericidal nanomaterials in food packaging: From principle to application.

J Food Sci

January 2025

Shandong Peanut Research Institute, Key Laboratory of Peanut Biology and Breeding, Ministry of Agriculture and Rural Affairs, Qingdao, PR China.

Compared to traditional preservatives, photodynamic inactivation (PDI) offers a promising bactericidal approach due to its nontoxic nature and low propensity for microbial resistance. In this paper, we initially investigate the principles and antibacterial mechanisms underlying PDI. We then review factors influencing PDI's germicidal efficacy in food preservation.

View Article and Find Full Text PDF

Plants and microorganisms coexist within complex ecosystems, significantly influencing agricultural productivity. Depending on the interaction between the plant and microbes, this interaction can either help or harm plant health. Microbes interact with plants by secreting proteins that influence plant cells, producing bioactive compounds like antibiotics or toxins, and releasing molecules such as N-acyl homoserine lactones to coordinate their behaviour.

View Article and Find Full Text PDF

The combination of polystyrene microplastics and di (2-ethylhexyl) phthalate promotes the conjugative transfer of antibiotic resistance genes between bacteria.

Ecotoxicol Environ Saf

January 2025

MOE Key Laboratory of Pollution Processes and Environmental Criteria/Tianjin Engineering Center of Environmental Diagnosis and Contamination Remediation, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China. Electronic address:

Plastic pollution has become a common phenomenon. The process of plastic degradation is accompanied by the release of microplastics and plasticizers. However, the coexistence of microplastics and plasticizers on the transfer of antibiotic resistance genes (ARGs) has not been reported until now.

View Article and Find Full Text PDF

Carbapenem resistant Acinetobacter baumannii has evolved as the most troublesome microorganism with multiple virulence factors. Biofilm formation, porins, micronutrient capturing mechanism and quorum sensing, provide protection against desiccation, host-pathogen killing and enhance its persistence. The conservation of these factors between colonizing and pathogenic carbapenem resistant A.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!