AI Article Synopsis
- Localisation of proteins in eukaryotes is crucial for their function, as they need to be in specific compartments to interact with relevant proteins.
- COLA is a new proteomics and bioinformatics approach designed to identify protein-protein co-localisations on a large scale, indicating potential functional relationships.
- This method enables quick and precise mapping of how protein interactions change under different conditions or treatments.
Article Abstract
Localisation and protein function are intimately linked in eukaryotes, as proteins are localised to specific compartments where they come into proximity of other functionally relevant proteins. Significant co-localisation of two proteins can therefore be indicative of their functional association. We here present COLA, a proteomics based strategy coupled with a bioinformatics framework to detect protein-protein co-localisations on a global scale. COLA reveals functional interactions by matching proteins with significant similarity in their subcellular localisation signatures. The rapid nature of COLA allows mapping of interactome dynamics across different conditions or treatments with high precision.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315029 | PMC |
| http://dx.doi.org/10.1039/c6mb00701e | DOI Listing |
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