Langerhan's histiocytosis is a not uncommon disease, but a related disorder, Rosai-Dorfman (RDD) with extensive or exclusive extranodal distribution, is relatively rare. Ga and PET/CT imaging have typically been used for diagnosis and tracking response to treatment. The authors present a very unusual case wherein lesions of RDD actively accumulated Tc-sestamibi, which was injected as part of a scan to localize a parathyroid adenoma.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/RLU.0000000000001380 | DOI Listing |
Clin Nucl Med
December 2024
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, India.
A 53-year-old woman of primary hyperparathyroidism with both ultrasound neck examination and planar 99m Tc-MIBI scan being negative revealed a tracer-avid focus in the left submandibular region in early (15 minutes postinjection) 99m Tc-MIBI SPECT/CT views, raising a suspicion of rare ectopic parathyroid adenoma. This finding was correlated on 4D-CT and confirmed on histopathology following surgical excision. Submandibular region is an unusual location for ectopic parathyroid adenoma.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
June 2024
Service of Otolaryngology and Head and Neck Surgery, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Technetium-99m sestamibi single-photon emission computed tomography/computed tomography (Tc-sestamibi SPECT/CT) is a mainstay of the pre-operative localization of parathyroid lesions. We report here the case of a 30 year-old woman with a fortuitously discovered 2 cm cervical mass for which a parathyroid origin was originally suspected due to its retro-thyroidal localization and a personal history of nephrolithiasis. Normal serum calcium and parathyroid hormone (PTH) levels excluded primary hyperparathyroidism, raising suspicion of a non-functional parathyroid adenoma, and SPECT/CT imaging showed that the mass was Tc-sestamibi-avid.
View Article and Find Full Text PDFJ Nucl Cardiol
December 2022
Department of Interventional Radiology, The First Hospital of China Medical University, Shenyang, China.
Purpose: Hypericin (Hyp) is a natural compound with a newly discovered necrosis-avidity, which can be exploited as a necrosis-avid tracer once labeled with radioactive iodine as has been tested in rodent models. This study was to evaluate the effect of radioiodinated Hyp (I-Hyp) for imaging detection of acute myocardial infarction (AMI) in conditions closer to clinical scenarios.
Methods: We established swine AMI models (n = 6) which were intravenously given I-Hyp and Tc-sestamibi and underwent SPECT-CT imaging with high- and low-energy collimators.
Clin Nucl Med
April 2022
From the Department of Nuclear Medicine and PET-CT, PD Hinduja National Hospital and Medical Research Centre, Mumbai, India.
MIBI scintigraphy is the most widely used modality to identify parathyroid adenomas preoperatively. However, MIBI is also known to accumulate in multiple benign and malignant lesions. In renal cell carcinoma, 30% of the patients present with distant metastasis, commonly lungs and bone; however, jaw bone metastases are extremely rare (<1% of oral malignancies).
View Article and Find Full Text PDFAsia Ocean J Nucl Med Biol
January 2022
Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!