Mepyramine maleate, aminophenazone, nialamide and chloroquine phosphate are examples of compounds which do not fulfil the requirements of the delta A method. By the proper choice of polynomial and wavelengths, the deltapj method has been successfully applied to their determination. The mean percentage recoveries were found to be 100.2 +/- 0.8, 99.6 +/- 0.6, 99.1 +/- 1.7 and 100.4 +/- 1.3, respectively.
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Res Commun Chem Pathol Pharmacol
June 1983
The addition of 1 mM of the metal complexing reagents such as EDTA, alpha, alpha'-dipyridyl, 1,10-phenanthroline and Tiron to the incubation of benzylamine, aminopyrine, p-nitroanisole and aniline, respectively, inhibited selectively the microsomal deamination of benzylamine, whereas the addition of the monoamine oxidase inhibitors tranylcypromine, nialamide and iproniazid specifically decreased the metabolism of aminopyrine, p-nitroanisole and aniline. Pretreatment of rats with 3,4-benzpyrene or phenobarbital increased the liver microsomal concentration of cytochrome P-450 (448) and the rate of aminopyrine and p-nitroanisole demethylation and of aniline hydroxylation whereas pretreatment cytochrome P-450 depressor agents such as cadmium or cobalt lowered the concentration of the hemoprotein and decreased the rate of the demethylation reactions. Phenobarbital and 3,4-benzpyrene pretreatment had either no effect or decreased significantly the rate of the microsomal deamination reaction respectively.
View Article and Find Full Text PDFMepyramine maleate, aminophenazone, nialamide and chloroquine phosphate are examples of compounds which do not fulfil the requirements of the delta A method. By the proper choice of polynomial and wavelengths, the deltapj method has been successfully applied to their determination. The mean percentage recoveries were found to be 100.
View Article and Find Full Text PDFAnn Univ Mariae Curie Sklodowska Med
August 1971
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