AI Article Synopsis
- In Vietnam, data on tetanus cases is lacking, prompting an analysis of 786 cases over 18 years to evaluate the impact of vaccination programs like the Expanded Program on Immunization (EPI) and the Maternal and Neonatal Tetanus (MNT) initiative.
- The median age of tetanus patients increased significantly from 33 years in 1994 to 46 years in 2012, showing that most cases were older adults who were born before the EPI was implemented.
- Testing showed that while 73.3% of women covered by MNT had anti-tetanus antibodies, only 24.4% of men had them, highlighting a continued vulnerability to tetanus among
Article Abstract
In Vietnam, there are no accurate data on tetanus incidence to allow assessment of disease burden or vaccination program efficacy. We analyzed age structure of 786 tetanus cases admitted to a tertiary referral center in Vietnam for three separate years during an 18-year period to examine the impact of tetanus prevention programs, namely the Expanded Program on Immunization (EPI) and the Maternal and Neonatal Tetanus (MNT) initiative. Most cases were born before the initiation of EPI. Median age increased from 33 (interquartile range: 20-52) in 1994, to 46 (32-63) in 2012 (P < 0.001). Birth-year distribution was unchanged, indicating the same birth cohorts presented with tetanus in 1994, 2003, and 2012. Enzyme-linked immunosorbent assay measurements in 90 men and 90 women covered by MNT but not EPI showed 73.3% (95% confidence interval [CI]: 62.9-82.1%) of women had anti-tetanus antibody compared with 24.4% (95% CI: 15.9-34.7%) of men, indicating continued tetanus vulnerability in older men in Vietnam.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239717 | PMC |
| http://dx.doi.org/10.4269/ajtmh.16-0470 | DOI Listing |
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