Using data from the 1995 and 2006-2010 National Survey of Family Growth, the authors study examined children's family instability from birth to age 12, emphasizing variation by racial and ethnic group. Period and cohort estimates revealed little change in children's experiences of family transitions during the past decade. Family instability levels were comparable for White and Hispanic children, and this pattern persisted over time. However, there was an increase in family instability among Black children, reflecting growth in the share of children born to single mothers who eventually formed partnerships. Indeed, children born to single mothers in the more recent cohort experienced more family transitions, on average, than did the earlier cohort, but family instability for children born to cohabiting mothers remained unchanged. This study elucidates the various family life course trajectories children experience, revealing how these patterns differ depending on family context at birth and by racial and ethnic group.
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http://dx.doi.org/10.1111/jomf.12311 | DOI Listing |
Sci Rep
December 2024
Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.
Solute transport family 7A member 7 (SLC7A7) mutations contribute to lysinuric protein intolerance (LPI), which is the mechanism of action that has been extensively studied. In colorectal cancer (CRC), SLC7A7 appears to play a role, but the features and mechanisms are not yet well understood. Survival was analyzed using the Kaplan-Meier analysis.
View Article and Find Full Text PDFCureus
November 2024
Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
Vulnerable groups, such as pregnant women and young children, can face barriers to timely and essential healthcare, primarily due to their dependence on caregivers. Medico-legal interventions are effective tools to protect high-risk populations when traditional methods fail. Based on my experience as a Medical Officer In-Charge of a Primary Health Center in rural Haryana, India, I present three case studies where legal assistance was used to ensure necessary medical care.
View Article and Find Full Text PDFJ Biol Chem
December 2024
Center for Mitochondrial Biomedicine and Department of Otolaryngology-Head and Neck Surgery, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang, China; Center for Genetic Medicine, Zhejiang University International Institute of Medicine, Yiwu, Zhejiang, China; Joint Institute of Genetics and Genomic Medicine between Zhejiang University and University of Toronto, Hangzhou, Zhejiang, China. Electronic address:
Human mitochondrial 12S ribosomal RNA (rRNA) 1555A>G mutation has been associated with aminoglycoside-induced and nonsyndromic deafness in many families worldwide. Our previous investigation revealed that the m.1555A>G mutation impaired mitochondrial translation and oxidative phosphorylation (OXPHOS).
View Article and Find Full Text PDFMed
December 2024
Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; Hematology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Background: Unstable hemoglobins are caused by single amino acid substitutions in the HBB gene, often affecting key histidine residues, leading to protein destabilization and hemolytic crises. In contrast, long HBB variants, exceeding 20 bp, are rare and associated with a β-thalassemia phenotype due to disrupted α-β chain interactions. We describe a family wherein four of six members carry a novel 23-amino-acid in-frame duplication of HBB (c.
View Article and Find Full Text PDFPurpose Of Review: To contextualize how pediatrics led the field in developing and implementing tools to screen for social determinants of health in clinical care as well as in creating innovative interventions to mitigate them, and to summarize where the evidence points as the next frontier.
Recent Findings: The evidence showed that health-related social needs (HRSN), like food insecurity, energy insecurity, and housing instability, continue to drive poor health outcomes across the lifespan; patients and healthcare providers are open to discussing HRSN in clinical settings, though some providers feel ill-equipped to do so; to mitigate HRSN, healthcare plays a unique role in ensuring patients' HRSN are understood, referring to effective resources through building strong, lasting relationships with community partners, embedding services in the healthcare setting across all departments, and empowering patient families to participate in programs and services; and administrative burden hinders families from getting all the benefits to which they are entitled, which streamlined co-enrollment processes can address.
Summary: Pediatric providers can add a unique and credible voice to seeking changes to the safety-net, including co-enrollment, that could reduce administrative burden, address patients' HRSN, and improve health starting in the prenatal period through later adulthood.
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