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Mechanistic Studies of the Anticancer Activity of An Octahedral Hexanuclear Pt(II) Cage. | LitMetric

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Article Abstract

The cellular response evoked by a hexanuclear platinum complex, PtL (), is reported. Compound , a 3-nm octahedral cage formed by self-assembly of six Pt(II) centers and four 2,4,6-tris(4-pyridyl)-1,3,5-triazine ligands (L), exhibits promising in vitro potency against a panel of human cancer cell lines. Unlike classical platinum-based anticancer agents, interacts with DNA in a non-covalent, intercalative manner and promotes DNA condensation. In cancer cells, induces DNA damage, upregulates p53, its phosphorylated form phospho-p53 and its downstream effector, p21, as well as both apoptosis and senescence.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094802PMC
http://dx.doi.org/10.1016/j.ica.2016.03.021DOI Listing

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