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Lower Switch Rate in Depressed Patients With Bipolar II Than Bipolar I Disorder Treated Adjunctively With Second-Generation Antidepressants.
Focus (Am Psychiatr Publ)
October 2023
From the Department of Psychiatry and Biobehavioral Sciences and Department of Biostatistics, School of Public Health, University of California, Los Angeles; Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; Department of Psychiatry, University Medical Center Groningen, the Netherlands; Biological Psychiatry Branch, NIMH, NIH, Bethesda, Md.; Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Mental Health Care Line and General Clinical Research Center, and Cincinnati VA Medical Center, Cincinnati; Altrech Institute for Mental Health Care, Utrecht, the Netherlands; and Department of Psychiatry, Ludwig-Maxmilians-Universitat Munich.
Objectives: The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder.
Methods: In a 10-week trial, 184 outpatients with bipolar depression (134 with bipolar I disorder, 48 with bipolar II disorder, two with bipolar disorder not otherwise specified) were treated with one of three antidepressants as an adjunct to mood stabilizers. The patients' switch rates were assessed.
Are personality disorders in bipolar patients more frequent in the US than Europe?
Eur Neuropsychopharmacol
May 2022
Biostatistician Bipolar Collaborative Network, Chevy Chase, MD, United States.
Objective: Bipolar patients in the United States (US) compared to those from the Netherlands and Germany (here abbrev. as "Europe") have more Axis I comorbidities and more poor prognosis factors such as early onset and psychosocial adversity in childhood. We wished to examine whether these differences also extended to Axis II personality disorders (PDs).
View Article and Find Full Text PDFMania and bipolar depression: complementing not opposing poles-a post-hoc analysis of mixed features in manic and hypomanic episodes.
Int J Bipolar Disord
November 2021
Department of Psychiatry and Psychotherapy Medical Center, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
Background: Depending on the classification system used, 5-40% of manic subjects present with concomitant depressive symptoms. This post-hoc analysis evaluates the hypothesis that (hypo)manic subjects have a higher burden of depression than non-(hypo)manic subjects.
Methods: Data from 806 Bipolar I or II participants of the Stanley Foundation Bipolar Network (SFBN) were analyzed, comprising 17,937 visits.
25 Years of the International Bipolar Collaborative Network (BCN).
Int J Bipolar Disord
April 2021
Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Background: The Stanley Foundation Bipolar Treatment Outcome Network (SFBN) recruited more than 900 outpatients from 1995 to 2002 from 4 sites in the United States (US) and 3 in the Netherlands and Germany (abbreviated as Europe). When funding was discontinued, the international group of investigators continued to work together as the Bipolar Collaborative Network (BCN), publishing so far 87 peer-reviewed manuscripts. On the 25th year anniversary of its founding, publication of a brief summary of some of the major findings appeared appropriate.
View Article and Find Full Text PDFStructural and Functional Connectivity of Visual Cortex in Schizophrenia and Bipolar Disorder: A Graph-Theoretic Analysis.
Schizophr Bull Open
January 2020
Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA.
Visual processing abnormalities in schizophrenia (SZ) are poorly understood, yet predict functional outcomes in the disorder. Bipolar disorder (BD) may involve similar visual processing deficits. Converging evidence suggests that visual processing may be relatively normal at early stages of visual processing such as early visual cortex (EVC), but that processing abnormalities may become more pronounced by mid-level visual areas such as lateral occipital cortex (LO).
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