Src-family tyrosine kinases and the Ca signal.

In this review, we shall describe the rich crosstalk between non-receptor Src-family kinases (SFKs) and the Ca transient generated in activated cells by a variety of extracellular and intracellular stimuli, resulting in diverse signaling events. The exchange of information between SFKs and Ca is reciprocal, as it flows in both directions. These kinases are main actors in pathways leading to the generation of the Ca signal, and reciprocally, the Ca signal modulates SFKs activity and functions. We will cover how SFKs participate in the generation of the cytosolic Ca rise upon activation of a series of receptors and the mechanism of clearance of this Ca signal. The role of SFKs modulating Ca-translocating channels participating in these events will be amply discussed. Finally, the role of the Ca sensor protein calmodulin on the activity of c-Src, and potentially on other SFKs, will be outlined as well. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.