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Background: Achieving bony union in scaphoid nonunion fractures is challenging. Various bone grafts have been studied using headless compression screws (HCS) fixation. However, the impact of bone graft choice on bone healing with volar locking plates (VLP) use is less clear.
View Article and Find Full Text PDFTreatment of Type IV Fragility Fractures of Pelvis With Robotic-Assisted Minimally Invasive Triangular Fixation.
Orthop Surg
December 2024
Department of Orthopaedic Trauma, Tianjin Hospital, Tianjin University, Tianjin, China.
Objective: Type IV fragility fractures of pelvis (FFP IV) are serious and complicated and the treatment is challengeable. Robotic-assisted minimally invasive triangular fixation (RoboTFX) is a new and advanced technique to treat this injury. The objective of this report is to evaluate the clinical outcomes of FFP IV treated with RoboTFX.
View Article and Find Full Text PDFThe Pattern of Cytokines, Chemokines, and Growth Factors of the Maxillary and Mandibular Periosteum After Exposure to Titanium Fixations-Ti6Al4V.
J Clin Med
November 2024
Department of Restorative Dentistry, Medical University of Bialystok, 15-089 Białystok, Poland.
Titanium miniplates and screws are commonly used in the surgical management of dentofacial deformities. Despite the opinion of the biocompatibility of these bone fixations, some patients experience symptoms of chronic inflammation around titanium implants even many years after their application. The aim of this study was to examine the levels of cytokines, chemokines, and growth factors released from the maxilla and mandible periosteum surrounding titanium fixations 11 months after the implantation procedure.
View Article and Find Full Text PDFHigh-dose modified-release formulation of a poorly soluble drug via twin-screw melt coating and granulation.
Int J Pharm
December 2024
Chemical and Biochemical Engineering, Rutgers University, 98 Brett Road, Piscataway, NJ 08854, USA. Electronic address:
Favipiravir, a high dose antiviral drug effective for oral treatment for COVID-19, with poor water solubility is formulated using a simple, low-cost melt coating and granulation methodology. High-dose (82.5 % w/w API) tablets (600 mg and 800 mg) with desired release profiles are developed while minimizing excipient burden.
View Article and Find Full Text PDFFinite element analysis of intramedullary nailing and nail-plate combinations for treating unstable proximal tibial metaphyseal fractures.
Ulus Travma Acil Cerrahi Derg
January 2024
Department of Orthopedics and Traumatology, Mersin VM Medical Park Hospital, Mersin-Türkiye.
Background: The anatomy of the proximal tibia presents treatment challenges, and there is currently no widely accepted surgical fixation method for fractures in this region. The aim of this study is to evaluate the efficacy, benefits, and differences between intramedullary nailing (IMN) with a 4-hole Limited Contact Dynamic Compression Plate (LC-DCP) combination and IMN with an 8-hole LC-DCP combination in unstable fractures of the proximal metaphyseal region of the tibia.
Methods: An oblique fracture was created in the metaphyseal region, forming a 30-degree angle in the sagittal plane in three tibial models.
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