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Distinct MRI-based functional and structural connectivity for antidepressant response prediction in major depressive disorder.
Clin Neurophysiol
April 2024
School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, China; Child Development and Learning Science, Key Laboratory of Ministry of Education, Nanjing 210096, China. Electronic address:
Objective: Emerging studies have identified treatment-related connectome predictors in major depressive disorder (MDD). However, quantifying treatment-responsive patterns in structural connectivity (SC) and functional connectivity (FC) simultaneously remains underexplored. We aimed to evaluate whether spatial distributions of FC and SC associated treatment responses are shared or unique.
View Article and Find Full Text PDFGlofitamab in relapsed/refractory diffuse large B-cell lymphoma: Real-world data.
Hematol Oncol
October 2023
Department of Internal Medicine, Division of Hematology, Koc University School of Medicine, Istanbul, Turkey.
Article Synopsis
- Glofitamab is a bi-specific antibody used to treat relapsed or refractory B-cell lymphoma, showing potential in a phase II trial, but real-world data is limited.
- A retrospective study in Turkey analyzed 43 DLBCL patients receiving glofitamab, revealing median overall survival of 8.8 months and a 1-year progression-free survival rate of 83%.
- While the treatment had promising effectiveness, toxicity was a significant concern, with deaths linked to disease progression and treatment-related side effects like cytokine release syndrome.
Permanent Impairment of Language Functions in an Adolescent Case of Autoimmune Encephalitis.
Noro Psikiyatr Ars
October 2022
Marmara University, Faculty of Medicine, Department of Pediatrics, Division of Child Neurology, İstanbul, Turkey.
Introduction: In pediatric and adolescent population, autoimmune encephalitis (AE) may present with a wide variety of symptoms including cognitive regression accompanied with loss of language skills. Despite its high prevalence in AE, linguistic functions have not been investigated in extensive detail.
Case: A 12-year-old girl with no significant premorbid history and normal school performance presented with fever, hypersomnia, nocturnal myoclonus and behavioral changes.
The Relationship Between Frontostriatal Connectivity and Striatal Dopamine Function in Schizophrenia: An 18F-DOPA PET and Diffusion Tensor Imaging Study in Treatment Responsive and Resistant Patients.
Psychiatry Investig
July 2022
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
Objective: Striatal dopamine dysfunction caused by cortical abnormalities is a leading hypothesis of schizophrenia. Although prefrontal cortical pathology is negatively correlated with striatal dopamine synthesis, the relationship between structural frontostriatal connectivity and striatal dopamine synthesis has not been proved in patients with schizophrenia with different treatment response. We therefore investigated the relationship between frontostriatal connectivity and striatal dopamine synthesis in treatment-responsive schizophrenia (non-TRS) and compared them to treatment-resistant schizophrenia (TRS) and healthy controls (HC).
View Article and Find Full Text PDFCingulum bundle connectivity in treatment-refractory compared to treatment-responsive patients with bipolar disorder and healthy controls: a tractography and surgical targeting analysis.
J Neurosurg
September 2022
4Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.
Objective: The clinical response of patients with bipolar disorder to medical treatment is variable. A better understanding of the underlying neural circuitry involved in bipolar treatment responsivity subtypes may provide insight into treatment resistance and aid in identifying an effective surgical target for deep brain stimulation (DBS) specific to the disorder. Despite considerable imaging research related to the disease, a paucity of comparative imaging analyses of treatment responsiveness exists.
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