AI Article Synopsis
- Asthma is an inflammatory disease affecting the airways, and acupuncture is commonly used as a treatment in China.
- A study evaluated acupuncture's effects on airway inflammation and the HPA axis in a mouse model of asthma, showing it can reduce airway hyper-responsiveness and immune cell counts.
- The results indicate that acupuncture helps decrease airway inflammation and regulates HPA axis activity by promoting key hormone secretion, adding insights into how acupuncture can aid asthma management.
Article Abstract
Asthma is a complex inflammatory disease of the airways and acupuncture is one of the effective therapies widely used to treat asthma in China. The aim of the study was to evaluate the regulatory role of acupuncture in airway inflammation and the hypothalamic-pituitary-adrenal (HPA) axis activity in OVA-induced murine asthma model. Our results demonstrated that acupuncture was effective in suppression of AHR, inhibition of total leukocyte, neutrophil, lymphocyte and eosinophil counts in BALF, attenuation of airway inflammation and TNF-α, IL-1β, IL-5 and eotaxin secretion. Furthermore, the HPA axis activity was also regulated by acupuncture, which included promotion of adrenocorticotropic hormone and cortisol secretion in the plasma. Our findings revealed that acupuncture could attenuate airway inflammation and regulate HPA axis and immunologic function in the OVA-induced murine asthma model, which may provide support to better understand the contribution of acupuncture to the regulation of airway inflammation and HPA axis activity in asthma.
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| http://dx.doi.org/10.1016/j.neulet.2016.11.001 | DOI Listing |
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