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The Association between Systemic Inflammation and the Prostate Cancer: based on the National Health and Nutrition Examination Survey and Mendelian Randomization Analysis.
Urol J
November 2024
2. Department of Urology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Article Synopsis
- This research aimed to explore how systemic inflammation is related to the risk of developing prostate cancer (PCa), using data from the National Health and Nutrition Examination Survey (NHANES) and Mendelian randomization analysis.
- The study analyzed data from 7,706 participants aged 40 and older, finding that higher levels of systemic inflammation, measured by the systemic immune-inflammation index (SII), were linked to an increased risk of PCa, with specific immune cells also showing a causal relationship with the disease.
- The findings underscore the importance of systemic inflammation and immune responses as potentially modifiable factors that could influence the risk of prostate cancer.
The relationship between immune cells and prostate cancer, and the mediating role of metabolites: a Mendelian randomization study.
Sci Rep
October 2024
Department of Urology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, ZhuZhou, People's Republic of China.
Research has demonstrated the significant involvement of immune cells in the development and progression of prostate cancer (PCa). However, the precise causal relationship between immune cells and PCa remains unclear. This study utilized bidirectional Mendelian randomization (MR) analysis to investigate the causal link between immune cells and PCa.
View Article and Find Full Text PDFImpact of Nitric Oxide on Polymorphonuclear Neutrophils' Function.
Biomedicines
October 2024
Department of Anaesthesiology, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
Background: There is increasing evidence that nitric oxide (nitrogen monoxide, NO) significantly influences immune cellular responses, including those from polymorphonuclear leukocytes (PMNs).
Objective: The aim of this study was to examine a possible effect of NO on PMNs' function (chemotaxis, production of reactive oxygen species (ROS), and NETosis) using live cell imaging. Moreover, we investigated PMN surface epitope and neutrophil oxidative burst under the influence of NO by flow cytometric analysis.
Causal association of immune cells and endometritis: a Mendelian randomization study.
Sci Rep
October 2024
The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, No. 3002 Sungang West Road, Futian District, Shenzhen, 518000, Guangdong, China.
Research exploring the link between immune cell profiles and the development of endometritis remains scant. This gap necessitates further study to decode the complex interrelations influencing this condition. In this analysis, we leveraged two-sample Mendelian randomization to examine the causal ties between the phenotypes of immune cells and the incidence of endometritis.
View Article and Find Full Text PDFExploring the genetic association between immune cells and susceptibility to osteonecrosis using large-scale population data.
Heliyon
July 2024
Department of Orthopaedic, 920th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Kunming, Yunnan, China.
Objectives: Research shows a close association between aberrant immune reactions in osteonecrotic tissues and immune cell infiltration. However, due to limitations in sample size and dataset comprehensiveness, the causal relationship between them is not fully established. This study aims to determine whether there is a causal relationship using a larger and more diverse dataset.
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