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Application of subcutaneous extracellular matrix to prepare bilayer heparin-coated polycaprolactone/decellularized small-diameter vascular graft for tissue regeneration.
Int J Biol Macromol
December 2024
Department of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery, Capital Medical University, Beijing 100053,China. Electronic address:
In clinical practice, the demand for functional small-diameter vascular grafts continues to increase. In this study, a decellularized aorta artery was inserted into a poly(caprolactone) (PCL) vascular scaffold for self-assembly in-vitro to create a hybrid scaffold. The hybrid scaffold was then implanted subcutaneously into the dorsal flanks and the subcutaneous extracellular matrix was applied for bilayer adhesion.
View Article and Find Full Text PDFFunctional Efficacy of Tissue-Engineered Small-Diameter Nanofibrous Polyurethane Vascular Grafts Surface-Modified by Methacrylated Sulfated Alginate in the Rat Abdominal Aorta.
ACS Appl Mater Interfaces
December 2024
Department of Tissue Engineering, School of Advanced Technologies in Medicine, Royan Institute, Tehran 16635-148, Iran.
Improved design to imitate natural vascular scaffolds is critical in vascular tissue engineering (VTE). Smooth muscle cells originating from surrounding tissues require larger pore sizes relative to those of endothelial progenitor cells found in the bloodstream. Furthermore, biofunctionalized scaffolds mimic the microenvironment, cellular function, and tissue morphogenesis.
View Article and Find Full Text PDFα-Ketoglutaric Acid Reprograms Macrophages by Altering Energy Metabolism to Promote the Regeneration of Small-Diameter Vascular Grafts.
ACS Biomater Sci Eng
November 2024
Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Small-diameter vascular grafts still cannot clinically replace autologous blood vessels due to high restenosis rates caused by long-term inflammatory infiltration. Foreign body reactions to vascular grafts induce macrophages to adopt the pro-inflammatory M1 phenotype, releasing inflammatory factors such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). This induces a phenotypic switch in smooth muscle cells, eventually leading to intimal hyperplasia.
View Article and Find Full Text PDFGlutamine synthetase accelerates re-endothelialization of vascular grafts by mitigating endothelial cell dysfunction in a rat model.
Biomaterials
March 2025
Key Laboratory for Biomechanics and Mechanobiology (Beihang University) of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, PR China. Electronic address:
Article Synopsis
- Endothelial cell (EC) dysfunction in the aorta contributes to atherosclerosis and complications in vascular grafts, prompting a need for research on its relationship with vascular remodeling.
- This study developed glutamine synthetase (GS) loaded vascular grafts (GSVG) to enhance endothelial metabolism, showing significant improvements in dysfunctional human umbilical vein endothelial cells (HUVECs) in laboratory tests.
- Results indicated that GSVG not only improved EC function but also influenced smooth muscle cell behavior, reduced inflammation, and promoted better vascular graft healing in an animal model.
Perfusion Bioreactor Conditioning of Small-diameter Plant-based Vascular Grafts.
Tissue Eng Regen Med
December 2024
Bioengineering Program, Fred DeMatteis School of Engineering and Applied Science, Hofstra University, 229 Science and Innovation Center, Hempstead, NY, 11549, USA.
Article Synopsis
- Vascular grafts typically made from synthetic materials face issues like thrombosis and intimal hyperplasia, especially in small diameters, prompting research into alternative options such as decellularized plant scaffolds.* -
- The study developed a novel bioreactor to precondition small-diameter vascular grafts made from decellularized leatherleaf viburnum, simulating physiological conditions to enhance cell density and reduce thrombus formation.* -
- Results showed that bioreactor conditioning improved the grafts’ endothelial cell density and suture retention while maintaining cell viability, indicating the potential of these plant-based grafts for vascular repair with lower risk of blood clots.*
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