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Osteosarcoma associated with cemento-osseous dysplasia: co-incidence or two related entities?
Oral Radiol
October 2024
Department of Craniofacial Biology, Pathology and Radiology, Faculty of Dentistry and WHO Collaborating Centre, University of the Western Cape, Cape Town, South Africa.
Background: Osteosarcoma of the jaws is a rare primary malignant tumor of bone. The clinical, radiological and histopathological features of a case associated with cemento-osseous dysplasia is presented.
Case Report: A 57-year-old mixed-race female presented with a large, progressive, swelling of the right mandible.
Recurrent cementoblastoma with multifocal growth and cellular atypia: a case report.
Diagn Pathol
April 2024
Division of Clinical Laboratory, Osaka University Dental Hospital, Suita, Osaka, Japan.
Background: Cementoblastoma is a rare odontogenic tumor characterized by the formation of osteocementum-like tissue on a tooth root directly by neoplastic cementoblasts. Although it is categorized as benign, it has a high potential for growth with a certain degree of recurrence risk. However, there are only a few studies describing the features of recurrent cementoblastoma.
View Article and Find Full Text PDFOssifying fibroma mimiking jaw tumour: A radiographic dilema.
J Cancer Res Ther
January 2024
Department of Oral Medicine and Radiology, Darshan Dental College and Hospital, Loyara, Udaipur, Rajasthan, India.
Fibro-osseous lesions (FOLs) of the craniomaxillofacial region comprise a group of developmental, dysplastic, and neoplastic alterations. FOLs include ossifying fibromas (OF), cemento-ossifying fibroma (COF), familial gigantiform cementoma (FGC), fibrous dysplasia (FD), and cemento-osseous dysplasia (COD). Evidence suggests that some FOL, especially FD and OF may have a risk of spontaneous malignant transformation.
View Article and Find Full Text PDFComprehensive Genomic Analysis of Cemento-Ossifying Fibroma.
Mod Pathol
February 2024
Department of Human Genetics, McGill University, Montreal, Canada; Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil. Electronic address:
Cemento-ossifying fibroma (COF) of the jaws is currently classified as a benign mesenchymal odontogenic tumor, and only targeted approaches have been used to assess its genetic alterations. A minimal proportion of COFs harbor CDC73 somatic mutations, and copy number alterations (CNAs) involving chromosomes 7 and 12 have recently been reported in a small proportion of cases. However, the genetic background of COFs remains obscure.
View Article and Find Full Text PDFFamilial gigantiform cementoma with recurrent ANO5 p.Cys356Tyr mutations: Clinicopathological and genetic study with literature review.
Mol Genet Genomic Med
January 2024
Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing, P.R. China.
Background: Familial gigantiform cementoma (FGC) is a rare tumor characterized by the early onset of multi-quadrant fibro-osseous lesions in the jaws, causing severe maxillofacial deformities. Its clinicopathological features overlap with those of other benign fibro-osseous lesions. FGC eventually exhibits progressively rapid growth, but no suspected causative gene has been identified.
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