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Trichinella spiralis extracellular vesicles induce anti-inflammatory and regulatory immune responses in vitro.
Int J Parasitol
January 2025
The helminth Trichinella spiralis, through its excretory-secretory (ES L1) products, induces immune regulatory mechanisms that modulate the host's immune response not only to itself, but also to bystander antigens, foreign or self in origin, which can result in the alleviation of inflammatory diseases. Under the influence of ES L1, dendritic cells (DCs) acquire a tolerogenic phenotype and the capacity to induce Th2 and regulatory responses. Since ES L1 products represent a complex mixture of proteins and extracellular vesicles (TsEVs) the aim of this study was to investigate the impact of TsEVs, isolated from ES L1 products, on phenotypic and functional characteristics of DCs and to elucidate whether TsEVs could reproduce the immunomodulatory effects of the complete ES L1 product.
View Article and Find Full Text PDFFrontal midline theta reveals temporal dynamics of target amplification and distracter inhibition during mental set-shifting.
Int J Psychophysiol
January 2025
Department of Psychology, Technische Universität Dresden, Germany. Electronic address:
When humans shift between tasks, they initially show slower responses in the new task than in the previous one. Persisting attentional settings are increasingly recognized as a source for these shifting costs. However, the extent to which specific mechanisms underlying information selection and interference control contribute to this phenomenon remains less clear.
View Article and Find Full Text PDFPhosphorus-deficiency stress in cucumber ( L.) plants: early detection based on chosen physiological parameters and statistical analyses.
Photosynthetica
January 2024
Department of Plant Physiology, Institute of Biology, Warsaw University of Life Sciences-SGGW, 159 Nowoursynowska Street, 02-776 Warsaw, Poland.
Enhancing plant productivity and mitigating the impact of environmental stressors require a thorough understanding of phytomonitoring and physiological features indicative of plant health. This study delves into the response of cucumber plants to phosphorus deficiency employing diverse tools to identify key indicators and unravel the underlying mechanisms. Under phosphorus deficiency, a rapid response in older leaves was observed through the analysis of chlorophyll and carotenoid content.
View Article and Find Full Text PDFNative and cationic cellulose nanofibril films enriched with avocado seed compounds as a green alternative for potential wound care applications.
Int J Biol Macromol
January 2025
University of Maribor, Faculty of Chemistry and Chemical Engineering, Smetanova ulica 17, 2000 Maribor, Slovenia; University of Maribor, Faculty of Medicine, Taborska ulica 8, 2000 Maribor, Slovenia. Electronic address:
Cellulose nanofibrils (CNF) show great potential for skin wound care and healing due to their biocompatibility, non-cytotoxicity, and high swelling with good mechanical stability. In the presented study, for the first time native and cationized cellulose nanofibrils were used in combination with avocado seeds extracts obtained with different extraction methods (ASE), as an alternative to a well-known antibiotic, Clindamycin, to produce films with high and long-lasting antimicrobial efficacy. The swelling capacity of prepared films and extracts/antibiotic release kinetics were studied at different pH values to evaluate pH response behavior.
View Article and Find Full Text PDFThe association between maternal stress and human milk concentrations of cortisol and prolactin.
Sci Rep
November 2024
Laboratory of Anthropology, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa Street 9, Krakow, 30-387, Poland.
Psychosocial stress affects the relationship between prolactin (PRL) and cortisol (CORT). The dynamics of PRL and CORT changes under stress in human milk (HM) are largely unknown. We investigated how maternal stress related to recent life changes affects milk CORT and PRL concentrations.
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