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Theories behind Bacillus Calmette-Guérin failure in high-risk non-muscle-invasive bladder cancer and update on current management.
Cancer Pathog Ther
April 2024
Department of Urology, Frimley Park Hospital, Portsmouth Rd, Frimley, Camberley GU16 7UJ, United Kingdom.
Bladder cancer encapsulates a wide spectrum of disease severities, with non-muscle invasive bladder cancer (NMIBC) representing an entirely different entity from muscle-invasive disease. Bacillus Calmette-Guérin (BCG) is one of the most successful intravesical treatment methods for patients diagnosed. However, a considerable proportion of patients fail to respond to BCG treatment.
View Article and Find Full Text PDFCervical epidural hematoma masquerading as thrombosis of intracranial flow diverter in situ: A diagnostic and therapeutic conundrum.
Med J Armed Forces India
February 2023
Associate Professor (Neurosurgery), Guwahati Medical College and Hospital (GMCH), Guwahati, Assam, India.
Cervical epidural hematoma (EDH) is a rare but very serious cause of acute neurologic compression that needs early diagnosis and rapid intervention. Acute hemiparesis is an infrequent presentation of cervical EDH and often mimics cerebrovascular accident. In this case, we describe the management of a case of cervical EDH presenting as acute hemiparesis in an elderly female patient which mimicked as thrombosis of intracranial flow diverter in situ.
View Article and Find Full Text PDFRice lipases: a conundrum in rice bran stabilization: a review on their impact and biotechnological interventions.
Physiol Mol Biol Plants
July 2023
National Institute of Plant Genome Research (NIPGR), Aruna Asaf Ali Marg, New Delhi, 110067 India.
Unlabelled: Rice is a primary food and is one of the most important constituents of diets all around the world. Rice bran is a valuable component of rice, containing many oil-soluble vitamins, minerals, and oil. It is known for its ability to improve the economic value of rice.
View Article and Find Full Text PDFThe divergence of mutation rates and spectra across the Tree of Life.
EMBO Rep
October 2023
Institute of Evolution and Marine Biodiversity, KLMME, Ocean University of China, Qingdao, China.
Owing to advances in genome sequencing, genome stability has become one of the most scrutinized cellular traits across the Tree of Life. Despite its centrality to all things biological, the mutation rate (per nucleotide site per generation) ranges over three orders of magnitude among species and several-fold within individual phylogenetic lineages. Within all major organismal groups, mutation rates scale negatively with the effective population size of a species and with the amount of functional DNA in the genome.
View Article and Find Full Text PDFClose, but no cigar: an unfortunate case of primary angiitis of the central nervous system.
Ann Med Surg (Lond)
February 2023
Department of Rheumatology, Icahn School of Medicine at Mount Sinai Hospital, New York, New York, USA.
Unlabelled: Primary angiitis of the central nervous system (PACNS) is an uncommon and misunderstood disease, where little is known regarding its immunopathogenesis and appropriate treatment. Due to the constellation of nonspecific clinical features and imaging findings, PACNS is a diagnostic conundrum for clinicians and can be very difficult to treat.
Case Presentation: A 64-year-old male with a history of prostate cancer presented to the emergency department with expressive aphasia and severe headache.
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