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Concomitant Right Atrial Hemangioma Resection With LVAD Implantation: First-in-Human Experience.
JACC Case Rep
December 2024
Department of Cardiology, Medipol University Faculty of Medicine, Istanbul, Turkey.
Cardiac hemangiomas are exceedingly rare, comprising only 5% to 10% of benign cardiac tumors. We report a patient with a large right atrial mass and end-stage heart failure with severe left ventricular dysfunction. Echocardiography revealed a mass obstructing tricuspid inflow.
View Article and Find Full Text PDFEvaluation of the safety, biodistribution, dosimetry of [F]AlF-NYM005 and initial experience in clear cell renal cell carcinoma: an interim analysis of a prospective trial.
Eur J Nucl Med Mol Imaging
December 2024
Department of PET-CT, Harbin Medical University Cancer Hospital, Harbin, 150001, China.
Purpose: This first-in-human study aimed to evaluate the radiation dosimetry and whole-body biodistribution of [F]AlF-NYM005, a novel small-molecule carbonic anhydrase IX (CAIX) targeting agent, and to investigate its ability to detect CAIX-positive tumors using PET scans in a cohort of clear cell renal cell carcinoma (ccRCC) patients.
Methods: [F]AlF-NYM005 was synthesized using a fully automatic cassette module Mortenon M1 (Nuoyu, China). Thirty-five patients with a suspicious lesion considered primary renal malignancy or a history of ccRCC were prospectively recruited and studied.
First-in-human Evaluation of Safety and Dosimetry of [Cu]FBP8: A fibrin-binding PET Probe.
Mol Imaging Biol
December 2024
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteen St. Suite 2301, Boston, MA, 02129, USA.
Article Synopsis
- - The study investigates the safe use and distribution of a new imaging probe called [Cu]Fibrin Binding Probe #8 ([Cu]FBP8) in healthy individuals, focusing on its potential for thrombus imaging and pulmonary fibrosis detection.
- - Eight participants underwent PET/MRI sessions after receiving the probe, which showed quick blood clearance and renal excretion, with the urinary bladder and kidneys receiving the highest radiation doses.
- - Findings suggest that [Cu]FBP8 has low dosimetry, rapid clearance, and low background signal, making it a promising tool for non-invasive imaging in various medical conditions related to cardiovascular, cancer, and neurological issues.
First-in-human experience of a portable electrical drill with smart autostop for bedside external ventricular drain placement.
J Clin Neurosci
January 2025
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address:
Article Synopsis
- Timely placement of external ventricular drains (EVDs) is crucial in emergency neurosurgery, and the introduction of portable electrical drills like the Hubly drill offers potential improvements in the procedure.
- In a study, two patients successfully received EVDs using the new portable drill, with quick access times and no complications observed during the procedures.
- The findings suggest that the smart autostop feature of the drill could enhance safety and efficiency in EVD placement, highlighting the need for further development and research in this technology.
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