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Artificial Intelligence-Driven Precision Medicine: Multi-Omics and Spatial Multi-Omics Approaches in Diffuse Large B-Cell Lymphoma (DLBCL).
Front Biosci (Landmark Ed)
November 2024
Department of Hematology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, 317000 Taizhou, Zhejiang, China.
In this comprehensive review, we delve into the transformative role of artificial intelligence (AI) in refining the application of multi-omics and spatial multi-omics within the realm of diffuse large B-cell lymphoma (DLBCL) research. We scrutinized the current landscape of multi-omics and spatial multi-omics technologies, accentuating their combined potential with AI to provide unparalleled insights into the molecular intricacies and spatial heterogeneity inherent to DLBCL. Despite current progress, we acknowledge the hurdles that impede the full utilization of these technologies, such as the integration and sophisticated analysis of complex datasets, the necessity for standardized protocols, the reproducibility of findings, and the interpretation of their biological significance.
View Article and Find Full Text PDFAnalysing the relevance of TGF-β and its regulators in cervical cancer to identify therapeutic and diagnostic markers.
Gene
February 2025
Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India; Centre for Cancer Research, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India. Electronic address:
The role of transforming growth factor-beta (TGF-β) is dual, such that, it inhibits tumor development in initial stage and promotes metastasis in later stage. The present study is aimed to analyse the relevance of different types of TGF-β and their receptors on the overall survival (OS) and TGF-β driven gene expression in individuals with cervical cancer (CC) using ONCODB and GEPIA databases. The in-silico gene expression analysis showed, TGF-β1 and TGFβR2 are upregulated in cells infected with human papilloma virus (HPV)16, whereas, TGF-β2, TGFβR1 and TGFβR3 expression were downregulated.
View Article and Find Full Text PDFHigh performance Mg-Li dual metal-ion batteries based on highly pseudocapacitive hierarchical TiO-B nanosheet assembled spheres cathodes.
Nanotechnology
December 2024
IMDEA Materials Institute, C/ Eric Kandel 2, Getafe, Madrid, 28906, SPAIN.
Although Mg-Li dual metal-ion batteries are proposed as a superior system that unite safety of Mg-batteries and performance of Li-ion based systems, its practical implantation is limited due to the lack of reliable high performance cathodes. Herein, we report a high-performance Mg-Li dual metal-ion battery system based on highly pseudocapacitive hierarchical TiO2-B nanosheet assembled spheres (NS) cathode. This 2D cathode displayed exceptional pseudocapacitance (a maximum of 93%) specific capacity (303 mAh/g at 25 mA/g), rate performance (210 mAh/g at 1A/g), consistent cycling (retain ~100% capacity for 3000 cycles at 1A/g), coulombic efficiency (nearly 100%) and fast-charging (~12.
View Article and Find Full Text PDFWaste engine oil as a sustainable approach for asphalt rejuvenation and modification: A review.
Heliyon
December 2024
Department of Civil Engineering, Faculty of Engineering, Balochistan University of Information Technology, Engineering, and Management Sciences, 87300, Quetta, Pakistan.
The significant growth in road infrastructure worldwide over the last decade has resulted in a notable increase in the demand for asphalt binder. However, the utilization of asphalt binder in the road industry poses challenges to environmental sustainability and economic standpoints. The application of vehicular loads and exposure to environmental factors throughout the service life of roads contribute to the deterioration of binder properties, such as hardening and aging, ultimately leading to premature road failure.
View Article and Find Full Text PDFFrom Spores to Suffering: Understanding the Role of Anthrax in Bioterrorism.
Mil Med
December 2024
Division of Clinical Research and Medical Management (CRMM), Institute of Nuclear Medicine & Allied Sciences (INMAS), DRDO, Delhi 110054, India.
Introduction: Anthrax, caused by the bacterium Bacillus anthracis, stands as a formidable threat with both natural and bioterrorism-related implications. Its ability to afflict a wide range of hosts, including humans and animals, coupled with its potential use as a bioweapon, underscores the critical importance of understanding and advancing our capabilities to combat this infectious disease. In this context, exploring futuristic approaches becomes imperative, as they hold the promise of not only addressing current challenges but also ushering in a new era in anthrax management.
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