A novel method for the construction of allyl arylsulfone derivatives was developed by palladium catalyzed allylation of sulfonyl hydrazides with alkynes. A series of structurally diverse allyl arylsulfones can be regioselectively synthesized in high yields under mild conditions.
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Article Synopsis
- A new method was created to synthesize allylic sulfones from allylic alcohols and sulfonyl hydrazines using a mild process in water.
- The process utilizes the commercially available catalyst Pd(PPh) and operates effectively at 40 °C in the presence of air.
- This approach eliminates the need for nitrogen protection and organic solvents, making it easy to scale up for larger quantities, enhancing its practical applications.
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