The Protein Data Bank (PDB) is an archive of experimentally determined three-dimensional structures of proteins, nucleic acids, and other biological macromolecules with a 25 year history of service to a global community. PDB is being replaced by 3DB, the Three-Dimensional Database of Biomolecular Structures that will continue to operate from Brookhaven National Laboratory. 3DB will be a highly sophisticated knowledge-based system for archiving and accessing structural information that combines the advantages of object oriented and relational database systems. 3DB will operate as a direct-deposition archive that will also accept third-party supplied annotations. Conversion of PDB to 3DB will be evolutionary, providing a high degree of compatibility with existing software.
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http://dx.doi.org/10.6028/jres.101.025 | DOI Listing |
Neurobiol Aging
December 2024
Neuro-Bio Ltd., Building F5, Cuham Campus, Abingdon OX14 3DB, UK.
Age-related cognitive decline presents a healthcare challenge. While age-related mechanisms are mainly studied in humans, animal models provide key insights. Despite evidence of sex-specific differences in aging and cognition, the impact of age on female rodent behaviour is underexplored.
View Article and Find Full Text PDFSensors (Basel)
October 2024
Department of Physics, Physical Sciences Building, Aberystwyth University, Aberystwyth SY23 3BZ, UK.
Tropical cyclones (TC) are dynamic atmospheric phenomena featuring extreme low-pressure systems and powerful winds, known for their devastating impacts on weather and the environment. The main purpose of this paper is to consider the subtle involvement of TCs in the air quality index (AQI), focusing on aspects related to the air quality before, during and after cyclones. This research employs multimodal methods, which include meteorological data and different satellite observations.
View Article and Find Full Text PDFCancers (Basel)
September 2024
University of Exeter Medical School, University of Exeter, Exeter EX1 3DB, UK.
The platelet count, a component of the full blood count, has been identified as a useful diagnostic marker for cancer in primary care. The reference range for the platelet count is 150 to 400 or 450 × 10/L; this range does not account for natural variation in platelet count by age and sex. This study used three primary care cohorts from England, Canada, and Australia.
View Article and Find Full Text PDFPhilos Trans A Math Phys Eng Sci
October 2024
Materials Division, UK Atomic Energy Authority, Culham Science Centre, Abingdon, Oxfordshire OX14 3DB, UK.
The Spherical Tokamak for Energy Production (STEP) environment will include magnetic, thermal, mechanical and environmental loads far greater than those seen in the Joint European Torus campaigns of the past decade or currently contemplated for ITER. Greater still are the neutron peak dose rates of 10 displacements per atom, per second, which in-vessel materials in STEP are anticipated to be exposed to. Reduced activation and high-fluence resilience therefore dominate the materials strategy to support the STEP Programme.
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