Pd-catalyzed meta-C-H chlorination of anilines and phenols is developed using norbornene as the mediator. Heterocycles, including indole, thiophene, and indazole, are tolerated. The identification of a new pyridone-based ligand is crucial for the success of this meta-C-H chlorination reaction. Subsequent diverse transformations of the chlorinated products demonstrate the versatility of meta-C-H chlorination.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512287 | PMC |
| http://dx.doi.org/10.1021/jacs.6b11055 | DOI Listing |
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