To determine plasma markers of oxidative stress during the second and third trimester of pregnancy in patients with gestational diabetes mellitus (GDM). We conducted a prospective nested case-control study involving 400 pregnant women, 22 of whom developed GDM. As control group, 30 normal pregnant women were chosen randomly. Plasma samples were analyzed for 8-iso-prostaglandin F2 (8-iso-PGF2), advanced oxidative protein products (AOPPs), protein carbonyl (PCO), glutathione peroxidase-3 (GPX-3), and paraoxonase-1 (PON1) at 16-20 weeks, 24-28 weeks, and 32-36 weeks of gestation. Compared to control subjects, the plasma levels of PCO, AOPPs, and 8-iso-PGF2 were elevated at 16-20 weeks' and 32-36 weeks' gestation in GDM. There was no significant difference in PCO and 8-iso-PGF2 at 24-28 weeks in GDM. GPX-3 was statistically significantly increased at 16-20 weeks and 32-36 weeks in GDM. PON1 reduced in patients with GDM. No significant differences were found at 24-28 and 32-36 weeks between the GDM and control groups. In GDM, PCO, AOPPs, and 8-iso-PGF2 levels were higher and GPX-3 and PON1 levels were lower in the second than the third trimester. Oxidation status increased in GDM, especially protein oxidation, which may contribute to the pathogenesis of GDM.
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| http://dx.doi.org/10.1155/2016/3865454 | DOI Listing |
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