We report a new approach for the detection of mitochondrial flavins through photo-oxidation of a probe molecule. Probe 1 showed high brightness (ε × Φ = 6.50 × 10 M cm) at long wavelengths (maximum emission wavelength, λ = 600 nm) upon photo-oxidation, assisted by the strong electron accepting ability of the isoalloxazine moiety in flavins. Probe 1 also exhibited high selectivity for flavins over various biological oxidants, remarkable photo-stability, and mitochondrial localization.
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| http://dx.doi.org/10.1039/c6cc07483a | DOI Listing |
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