AI Article Synopsis
- Herpes simplex virus type 2 (HSV-2) during pregnancy can lead to serious consequences, such as transmission to the newborn, and the study aimed to investigate the incidence and risk factors for HSV-2 seroconversion among pregnant women in Uganda.
- A prospective study was conducted with 200 HSV-2-negative women, using serological testing and interviews to gather data on their sexual history and other risk factors.
- Results showed that 7.9% of participants seroconverted, with identified risk factors including having multiple sexual partners, being in polygamous relationships, and being HIV-positive, highlighting the need for improved health education on sexual health during pregnancy.
Article Abstract
Introduction: Herpes simplex virus type 2 (HSV-2) acquired during pregnancy is associated with adverse outcomes such as perinatal HSV-2 transmission. HSV-2 seroconversion occurs within four weeks of HSV-2 acquisition. There was neither documented incidence nor risk factors for HSV-2 seroconversion during pregnancy in Uganda. The objective of this study was to determine the incidence and risk factors for HSV-2 seroconversion among pregnant women in Mulago Hospital, Uganda.
Methodology: A prospective study of 200 consenting HSV-2-negative women between 26 and 28 weeks of gestation was done between November 2013 and October 2014. HSV-2 serostatus was determined using HerpeSelect HSV-2 enzyme-linked immunosorbent assay (ELISA). Interviewer-administered questionnaires were used to collect socio-demographic characteristics and sexual history. Human immunodeficiency virus (HIV) serostatus was obtained from antenatal records. A total of 191 women completed follow-up and repeat HSV-2 serology by 38 weeks. Negative binomial regression analysis was used to estimate risk ratios for risk factors for HSV-2 seroconversion.
Results: Of 191 women, 15 (7.9%) seroconverted during pregnancy. Having multiple sexual partners, being in polygamous unions, and having HIV-positive serostatus were found to be risk factors for HSV-2 seroconversion.
Conclusions: The incidence of HSV-2 seroconversion during pregnancy in Uganda was high. Multiple sexual partners, polygamy, and HIV-positive serostatus were risk factors for HSV-2 seroconversion during pregnancy. Strengthening health education on the avoidance of multiple sexual partners during pregnancy is paramount in prevention of HSV-2 seroconversion.
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| http://dx.doi.org/10.3855/jidc.6874 | DOI Listing |
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