The Prevalence of Skin and Soft Tissue Infections in Patients with Pemphigus.

Pemphigus vulgaris are autoimmune blistering diseases that may result in significant morbidity and death. Immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. The aim of this study was to assess the prevalence of infection and gene in patients with pemphigus admitted to dermatology clinic. . This descriptive study was conducted on 196 pemphigus vulgaris patients (119 males, 77 females) admitted to dermatology clinic between 2014 and 2015. In this study, the diagnosis of pemphigus vulgaris was made by histology, immunofluorescence pattern of perilesional skin, and indirect immunofluorescence testing of serum. Data were collected through a questionnaire. . 59.1% of pemphigus vulgaris patients had infection. 49 out of 116 were methicillin-resistant. gene was detected in 25 out of 116 positive patients. . This is the first report of infection in pemphigus patients in Iran. More than forty percent of isolates were methicillin-resistant . gene carried by methicillin-resistant was high in this study.