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Activation of the HPA Axis Does Not Explain Nonresponsiveness to GLP-1R Agonist Treatment in Individuals With Type 2 Diabetes.
Diabetes
February 2025
Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands.
Article Synopsis
- * Researchers looked at the effects of GLP-1R agonists on the HPA axis and cortisol levels in individuals with varying responses to the treatment using advanced imaging techniques.
- * Results showed that pituitary GLP-1R expression was present in all participants, and while there were some differences by sex, the study concluded that HPA axis stimulation doesn't explain why some people poorly respond to GLP-1R agonists, suggesting the need for more research.
My boss is younger, less educated, and shorter tenured: When and why status (in)congruence influences promotion system justification.
J Appl Psychol
September 2023
Department of Management, Columbia University.
Supervisors are usually older, more educated, and longer tenured than their subordinates, a situation known as status congruence. However, subordinates are increasingly experiencing , in which their supervisors lack these traditional status markers. We examine how status congruence versus incongruence interacts with subordinates' judgments of their supervisors' competence to influence subordinates' perceptions of the promotion system.
View Article and Find Full Text PDF"What Would Give Her the Best Life?": Understanding Why Families Decline Pediatric Home Ventilation.
J Palliat Med
July 2023
Treuman Katz Center for Pediatric Bioethics, Seattle Children's Research Institute, Seattle, Washington, USA.
Families who must decide about pediatric home ventilation rely on the clinicians who counsel them for guidance. Most studies about pediatric home ventilation decisions focus on families who opt for this intervention, leaving much unknown about the families who decline. To describe the rationales of families who decline home ventilation.
View Article and Find Full Text PDFPersistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length in the National Health and Nutrition Examination Survey.
Sci Rep
November 2022
Department of Epidemiology and Center for Social Epidemiology and Population Health, University of Michigan, 1415 Washington Heights, 4659 SPH Tower, Ann Arbor, MI, 48109-2029, USA.
Despite racial disparities in diseases of aging and premature mortality, non-Hispanic Black Americans tend to have longer leukocyte telomere length (LTL), a biomarker of cellular aging, than non-Hispanic White Americans. Previous findings suggest that exposure to certain persistent organic pollutants (POPs) is both racially-patterned and associated with longer LTL. We examine whether Black/White differences in LTL are explained by differences in exposure to 15 POPs by estimating the indirect effect (IE) of self-reported race on LTL that is mediated through nine polychlorinated biphenyls (PCBs), three furans, and three dioxins, as well as their mixtures.
View Article and Find Full Text PDFVertebroplasty and Kyphoplasty.
Phys Med Rehabil Clin N Am
May 2022
Division of Pain Management, Pain Medicine Fellowship Program, Department of Anesthesia and Critical Care, University of Chicago Medical Center, 5841 S. Maryland Avenue, MC 4028, Chicago, IL 60637, USA. Electronic address:
Vertebral fractures are a common problem in the United States, which is why copious research has been performed to determine the best approaches to repair such fractures-including determining the least invasive procedures with the greatest benefits and fewest complications. In the past 3 decades, vertebral augmentation procedures (VAPs) have been very effective, with new techniques appearing in the field that has very reasonable outcomes and marked improvement in patients' quality of life. This article highlights the different VAPs approaches-comparing the advantages, disadvantages, and potential side effects of each approach.
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