Background: The circulatory pathway for particles deposited outside of blood capillaries has not been well characterized for non-traditionally-delivered chemotherapeutics.
Materials And Methods: Blood and lymph pharmacokinetics of docetaxel (5 mg/kg) and carboplatin (14 and 28 mg/kg) following subcutaneous (s.c.) versus intravenous (i.v.) delivery were determined in a rodent model with catheterizations of both the thoracic lymphatic duct and jugular vein for prolonged synchronous blood and lymph sampling.
Results: Subcutaneous docetaxel demonstrates preferential lymphatic accumulation based on the area under the time-concentration curve (AUC) whereas i.v. docetaxel resulted in a greater plasma maximum concentration measured (C). The apparent elimination half-life (t) in lymph for docetaxel is greater following i.v. or s.c. delivery compared to t in blood. Carboplatin demonstrates a dose-dependent increase in plasma C regardless of delivery route; the total carboplatin exposure over 24 h in lymph and plasma are comparable.
Conclusion: Subcutaneous docetaxel achieves lymphatic accumulation greater than that of i.v. delivery.
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| http://dx.doi.org/10.21873/anticanres.11076 | DOI Listing |
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