AI Article Synopsis
- * A large genome-wide association study analyzed data from over 340,000 individuals, identifying 12 genetic loci linked to AFB and NEB, plus 4 more through gene-based analysis.
- * These identified loci contain genes that may directly impact reproduction and infertility, enhancing our understanding of these complex traits.
Article Abstract
The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695684 | PMC |
| http://dx.doi.org/10.1038/ng.3698 | DOI Listing |
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