Despite recent advances in surgery, medicine and anaesthesiology as well as the development of microsurgical tissue transplantation, wear out of body parts remains a problem, and organ shortage does not allow to allocate enough donor organs for patients with vital diseases and conditions. The idea to create spare parts or spare organs from the patients own cells by combining engineering approaches to cellular and molecular medicine for th purpose of Tissue Engineering (TE) was fascinating when popularized in the early 1990ies. However clinically success was limited, mainly because of a lack in rapid vascularization of large scale TE replacement constructs useful for clinical purposes. The idea to utilize cells and cytokines to aid the human organism in gradually restoring lost tissue functions has drawn attention to the wider field of Regenerative Medicine (RM). Stem cells and putative stem cells, such as the recently discovered and meanwhile well described interstitial Telocytes, which are comprised of extremely long and thin prolongations named telopodes, may well become active players in the regenerative process. This article highlights the principles of TE and RM and the potential role of Telocytes with regard to tissue regeneration.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-981-10-1061-3_9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems.
iScience
January 2025
Institute of Neuroscience and Medicine 10, Research Centre Jülich, 52425 Jülich, Germany.
The / gene, linked to fine motor control in vertebrates, is a potential candidate gene thought to play a prominent role in human language production. It is expressed specifically in a subset of corticothalamic (CT) pyramidal cells (PCs) in layer 6 (L6) of the neocortex. These L6 FOXP2+ PCs project exclusively to the thalamus, with L6a PCs targeting first-order or both first- and higher-order thalamic nuclei, whereas L6b PCs connect only to higher-order nuclei.
View Article and Find Full Text PDFIFN-γ licenses normal and pathogenic ALPK1/TIFA pathway in human monocytes.
iScience
January 2025
CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, University Lyon, F-69007 Lyon, France.
Alpha-kinase 1 (ALPK1) is an immune receptor sensing the bacterial nucleotide sugar ADP-heptose. ALPK1 phosphorylates TIFA leading to its oligomerization and downstream NF-κB activation. Specific mutations in are associated with an autoinflammatory syndrome termed ROSAH and with spiradenoma (skin cancers with sweat gland differentiation).
View Article and Find Full Text PDFOver the last decade, Hippo signaling has emerged as a major tumor-suppressing pathway. Its dysregulation is associated with abnormal expression of and -family genes. Recent works have highlighted the role of YAP1/TEAD activity in several cancers and its potential therapeutic implications.
View Article and Find Full Text PDFBioprinting approaches in cardiac tissue engineering to reproduce blood-pumping heart function.
iScience
January 2025
Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea.
The heart, with its complex structural and functional characteristics, plays a critical role in sustaining life by pumping blood throughout the entire body to supply nutrients and oxygen. Engineered heart tissues have been introduced to reproduce heart functions to understand the pathophysiological properties of the heart and to test and develop potential therapeutics. Although numerous studies have been conducted in various fields to increase the functionality of heart tissue to be similar to reality, there are still many difficulties in reproducing the blood-pumping function of the heart.
View Article and Find Full Text PDFFacilitating children's communication in problem-solving activities with a coding toy: teachers' semiotic mediation in early childhood education and care.
Front Psychol
January 2025
Department of Early Childhood Education, University of Stavanger, Stavanger, Norway.
This study investigates the role of teacher mediation in facilitating children's communication during problem-solving, play-based coding activities with Kubo, a screen-free coding toy, in Early Childhood Education and Care (ECEC) settings. Following an initial observation involving nine kindergarten teachers and 36 children, a workshop was held to identify elements that teachers considered relevant for facilitating children's use of verbal and non-verbal communication. Key mediation elements, such as multimodal communication, planning, time, humor, and reflective questioning, were identified during the workshop and applied in a subsequent observation with the same participants.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!