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Purpose: To investigate relationships between intravoxel incoherent motion (IVIM) metrics of invasive ductal carcinoma of the breast and prognostic factors.
Materials And Methods: This retrospective study included a total of 82 masses from 72 patients who underwent 3T breast magnetic resonance imaging (MRI) and diffusion-weighted imaging. IVIM metrics of tissue diffusivity (D ), pseudodiffusivity (D ), and perfusion fraction (D ) were measured using histogram analysis for whole lesion volumes. We evaluated relationships between IVIM metrics and prognostic factors or subtypes of invasive ductal carcinoma.
Results: The D 50 , 75 , and 90 percentile metrics were reduced in the estrogen receptor (ER)-positive group compared with the ER-negative group (individually, P = 0.044, 0.024, 0.045). Additionally, the D 75 percentile value was a significant differentiator of histologic grade, tumor subtype, and Ki-67 grouping (individually, P = 0.024, 0.049, 0.016). The D mean, 75 , 90 percentile, skewness, and kurtosis metrics were correlated with the size of ductal carcinoma in situ (DCIS) component (individually, P = 0.034, 0.032, 0.027, 0.013, 0.013).
Conclusion: The D metrics differentiated between ER-positive and -negative groups, and the D metrics were associated with the size of the DCIS component.
Level Of Evidence: 4 J. MAGN. RESON. IMAGING 2017;45:1394-1406.
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