AI Article Synopsis
- Researchers investigated a deep-sea sediment-derived bacterium (B5) to find new natural products with anti-inflammatory properties.
- A new compound, identified as 7,13-epoxyl-macrolactin A, was isolated and showed stronger anti-inflammatory effects than previously known macrolactins due to its unique epoxy ring structure.
- The compound effectively inhibited mRNA expressions of inflammatory markers (iNOS, IL-1β, and IL-6) in stimulated macrophages, demonstrating its potential for future anti-inflammatory applications.
Article Abstract
In order to find new natural products with anti-inflammatory activity, chemical investigation of a 3000-meter deep-sea sediment derived bacteria B5 was carried out. A new macrolactin derivative was isolated and identified as 7,13-epoxyl-macrolactin A (). Owing to the existence of the epoxy ring, exhibited a significant inhibitory effect on the expression of inducible nitric oxide and cytokines, compared with previously isolated known macrolactins (-). Real-time Polymerase Chain Reaction (PCR) analysis showed that the new compound significantly inhibited the mRNA expressions of inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Reverse transcription-PCR analysis demonstrated that the new compound reduced the mRNA expression level of IL-1β in a concentration-dependent manner.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128738 | PMC |
| http://dx.doi.org/10.3390/md14110195 | DOI Listing |
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