This meta-analysis was designed to evaluate radiotherapy (RT) options preferable for neck cancer metastases from unknown primary sites (NCUP). Relevant articles published up through September 2015 were selected from EMBASE, Cochrane, PubMed and Web of Science. Thirty-three articles were identified, and relative risks (RRs) and 95% CIs for all pre-specified endpoints were calculated. Surgery plus RT showed an advantage for 5-year overall survival (OS) (RR 0.66, 95% CI 0.52-0.83, p = 0.0004) and neck recurrence (NR) (RR = 0.74, 95% CI 0.59-0.92, p = 0.008) compared to RT alone. The RRs for NR, primary tumor emergence (PTE), and 5-year disease free survival (DFS) for bilateral neck compared to ipsilateral neck irradiation were 0.61 (95% CI 0.41-0.91, p = 0.01), 0.44(95% CI 0.26-0.77, p = 0.004), and 0.81 (95% CI 0.64-1.03, p = 0.09), respectively. Irradiation of the neck plus potential primary tumor sites (PPTS) showed a benefit for 5-year DFS (RR 0.75, 95% CI 0.61-0.92, p = 0.005), NR (RR = 0.72, 95% CI 0.56-0.92, p = 0.009), and PTE (RR = 0.23, 95% CI 0.12-0.45, p < 0.0001) compared to neck-only irradiation. Adverse events occurred more frequently with bilateral neck plus PPTS irradiation. For NCUP, surgery plus RT of the bilateral neck and PPTS was associated with greater improvement of clinical outcomes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346673 | PMC |
| http://dx.doi.org/10.18632/oncotarget.12852 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Full-Endoscopic Anterior Cervical Decompression and Fusion for Cervical Myelopathy.
Neurospine
December 2024
Morgenstern Institute of Spine, Centro Médico Teknon, Barcelona, Spain.
This article aims to introduce a novel full-endoscopic anterior cervical discectomy and fusion (ACDF) procedure to treat cervical myelopathy. Adoption of endoscopic anterior cervical procedures has been lagging due to safety concerns and the necessity of placing an interbody cage. We have developed novel instrumentation and a modified percutaneous anterior cervical approach that allows a safe and reproducible full-endoscopic ACDF.
View Article and Find Full Text PDF[Uremic Leontiasis Ossea: A Challenge in End-Stage Chronic Kidney Disease. About a Case].
Rev Med Chil
May 2024
Departamento de Nefrología, Clínica Dávila, Santiago, Chile.
Article Synopsis
- Uremic leontiasis ossia (ULO) is a rare condition linked to renal osteodystrophy in patients with end-stage chronic kidney disease (CKD) and secondary hyperparathyroidism (SHPTH), causing bone deformities that can lead to a 'leonine' facial appearance.
- The case study focuses on a 39-year-old female patient undergoing treatment, who exhibited significant symptoms and had elevated parathyroid hormone (PTH) levels, confirmed by CT scans.
- Treatment involves a multidisciplinary approach including surgery and management of SHPTH to correct anatomical issues and prevent further complications.
Successful Treatment of Descending Necrotizing Mediastinitis by Thoracotomy Using a Pedicled Omental Flap: A Case Report.
Cureus
December 2024
Thoracic Surgery, Fukuyama City Hospital, Fukuyama, JPN.
Descending necrotizing mediastinitis (DNM) is a severe, life-threatening infection that requires prompt diagnosis and aggressive surgical intervention. Management is particularly challenging when the condition is complicated by bilateral empyema and perivascular involvement. A 73-year-old woman presented with septic shock several days after experiencing pharyngeal pain.
View Article and Find Full Text PDFProphylactic use of duloxetine hydrochloride in oxaliplatin-induced first-bite syndrome.
Int Cancer Conf J
January 2025
Department of Otolaryngology-Head and Neck Surgery, Kagawa Rosai Hospital, Kagawa, Japan.
First-bite syndrome (FBS) is manifested as acute and severe pain in the parotid region occurring at the first bite of a meal. While most cases of FBS arise after surgeries involving the deep lobe of the parotid gland, chemotherapy-induced FBS is extremely rare. Some adverse effects of oxaliplatin resemble FBS, suggesting it may be under-recognized.
View Article and Find Full Text PDFQuality of life after prosthodontic rehabilitation in patients with bilateral total maxillectomy due to COVID-19-associated mucormycosis of the maxilla.
Arch Craniofac Surg
December 2024
Department of Dentistry, All India Institute of Medical Sciences Bhopal, Bhopal, India.
Article Synopsis
- COVID-19-related mucormycosis in India led to significant maxillectomy cases, prompting this study on post-surgery quality of life through prosthodontic rehabilitation.
- The research utilized questionnaire-based interviews with the Oral Health Impact Profile-14 (OHIP-14) and Obturator Functioning Scale (OFS) to assess changes in patients' quality of life before and after receiving interim obturators.
- Results indicated significant improvements in patients' quality of life, including better speech, swallowing, and psychological well-being post-rehabilitation, highlighting the importance of obturators in recovery.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!