The inter- or intramolecular oxidative carboamination of alkynes catalyzed by [pyTiClNPh] is reported. These multicomponent reactions couple alkenes, alkynes and diazenes to form either α,β-unsaturated imines or α-(iminomethyl)cyclopropanes via a Ti/Ti redox cycle. Each of these products is formed from a common azatitanacyclohexene intermediate that undergoes either β-H elimination or α,γ-coupling, wherein the selectivity is under substrate control.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496654 | PMC |
| http://dx.doi.org/10.1021/jacs.6b09939 | DOI Listing |
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